eF-site ID 4yhz-HLP PDB Code 4yhz Chain H, L, P click to enlarge Title Crystal structure of 304M3-B Fab in complex with H3K4me3 peptide Classification IMMUNE SYSTEM Compound Fab Heavy Chain Source (4YHZ) Sequence H:  EVQLVETGGGVVQPGRSLRLSCTASGFTFRDYWMSWVRQA PGKGLEWVADIHQDGQVRYYLDAVKGRFTISRDNAKSSLY LQMNSLGAEDTAVYYCARNFVRGFGWHFDLWGRGTLVTVS SASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNS GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKS L:  LTQPPSVSVAPGQTARITCGGTNIGDISVHWYQQRPGQAP LVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEA DYYCQVWDDSINAYVFGTGTKVTVLRTVAAPSVFIFPPSD SQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRGE P:  ARTXQTARK Description Functional site 1) chain H residue 31 type sequence D description binding site for residue GOL H 301 source : AC1 2) chain H residue 32 type sequence Y description binding site for residue GOL H 301 source : AC1 3) chain H residue 53 type sequence Q description binding site for residue GOL H 301 source : AC1 4) chain H residue 100 type sequence F description binding site for residue GOL H 301 source : AC1 5) chain H residue 100 type sequence F description binding site for residue GOL H 301 source : AC1 6) chain H residue 101 type sequence V description binding site for residue GOL H 301 source : AC1 7) chain H residue 101 type sequence V description binding site for residue GOL H 301 source : AC1 8) chain H residue 102 type sequence R description binding site for residue GOL H 301 source : AC1 9) chain H residue 106 type sequence W description binding site for residue GOL H 301 source : AC1 10) chain H residue 104 type sequence F description binding site for residue GOL H 302 source : AC2 11) chain H residue 106 type sequence W description binding site for residue GOL H 302 source : AC2 12) chain H residue 106 type sequence W description binding site for residue GOL H 302 source : AC2 13) chain P residue 4 type sequence X description binding site for residue GOL H 302 source : AC2 14) chain P residue 6 type sequence T description binding site for residue GOL H 302 source : AC2 15) chain H residue 30 type sequence R description binding site for residue GOL H 303 source : AC3 16) chain H residue 73 type sequence D description binding site for residue GOL H 303 source : AC3 17) chain H residue 74 type sequence N description binding site for residue GOL H 303 source : AC3 18) chain H residue 75 type sequence A description binding site for residue GOL H 303 source : AC3 19) chain H residue 27 type sequence F description binding site for residue GOL H 304 source : AC4 20) chain H residue 98 type sequence R description binding site for residue GOL H 304 source : AC4 21) chain H residue 16 type sequence R description binding site for residue GOL H 305 source : AC5 22) chain H residue 17 type sequence S description binding site for residue GOL H 305 source : AC5 23) chain L residue 36 type sequence Q description binding site for residue GOL L 301 source : AC6 24) chain L residue 38 type sequence R description binding site for residue GOL L 301 source : AC6 25) chain L residue 57 type sequence I description binding site for residue GOL L 301 source : AC6 26) chain L residue 58 type sequence P description binding site for residue GOL L 301 source : AC6 27) chain L residue 61 type sequence F description binding site for residue GOL L 301 source : AC6 28) chain L residue 80 type sequence G description binding site for residue GOL L 301 source : AC6 29) chain L residue 81 type sequence D description binding site for residue GOL L 301 source : AC6 30) chain L residue 58 type sequence P description binding site for residue GOL L 302 source : AC7 31) chain L residue 59 type sequence E description binding site for residue GOL L 302 source : AC7 32) chain L residue 60 type sequence R description binding site for residue GOL L 302 source : AC7 33) chain L residue 76 type sequence R description binding site for residue GOL L 302 source : AC7 34) chain L residue 67 type sequence G description binding site for residue SO4 L 303 source : AC8 35) chain L residue 68 type sequence N description binding site for residue SO4 L 303 source : AC8 36) chain L residue 69 type sequence T description binding site for residue SO4 L 303 source : AC8 37) chain H residue 33 type sequence W description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 38) chain H residue 50 type sequence D description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 39) chain H residue 103 type sequence G description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 40) chain H residue 106 type sequence W description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 41) chain L residue 29 type sequence D description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 42) chain L residue 90 type sequence W description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 43) chain L residue 97 type sequence Y description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 44) chain P residue 3 type sequence T description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 45) chain P residue 6 type sequence T description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 46) chain P residue 6 type sequence T description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 47) chain P residue 7 type sequence A description binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 source : AC9 48) chain P residue 2 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 49) chain L residue 14-25 type prosite sequence PGQTARITCGGT description AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PgqTArITCGGT source prosite : PS00178 50) chain P residue 3 type MOD_RES sequence T description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088 source Swiss-Prot : SWS_FT_FI2 51) chain P residue 4 type MOD_RES sequence X description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 52) chain P residue 5 type MOD_RES sequence Q description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI4 53) chain P residue 6 type MOD_RES sequence T description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI5 54) chain P residue 8 type MOD_RES sequence R description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 source Swiss-Prot : SWS_FT_FI6 55) chain P residue 9 type MOD_RES sequence K description N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI7 56) chain H residue 202-208 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 57) chain L residue 193-199 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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