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Title
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Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17 |
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Classification
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IMMUNE SYSTEM |
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Compound
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Envelope glycoprotein gp160 |
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Source
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Human immunodeficiency virus 1 (4YDI) |
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Sequence
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G: |
VWRDADTTLFCASDAKAYETEKHNVWATHACVPTDPNPQE
IHLDNVTEKFNMWKNNMVEQMHTDIISLWDQSLKPCVKLT
GGSAITQACPKVSFEPIPIHYCTPAGFAILKCKDEGFNGT
GLCKNVSTVQCTHGIKPVVSTQLLLNGSLAEKNITIRSEN
ITNNAKIIIVQLVQPVTIKCIRPDIRQAHCNVTRSRWNKT
LQEVAEKLRTYFGNKTIIFANSSGGDLEITTHSFNCGGEF
FYCNTSGLFNSTWYVNSTWNDTNDTITLPCRIKQIINMWQ
RAGQAMYAPPIPGVIKCESNITGLLLTRDGGKDNNVNETF
RPGGGDMRDNWRSELYKYKVVEI
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| H: |
QRLVQSGPQVRKPGSSVRISCETSGYTFNAYILHWFRQAP
GRSFEWMGWIKPKFGAVNYAHSFQGRITLTRDIYRETAFL
DLTGLRFDDTAVYYCARDRLYDGSSWRLDPWGQGTRVVVS
SASTKGPSVFPLLGCLVKDYFPEPVTVSWNSGALTSGVHT
FPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT
KVDKKVEPK
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| L: |
IQMTQSPSSLAVSVGGRVTITCRASQGIGSDLHWYQQKRG
RPPKILIHHASAREEGVPSRFGGSGSHTPFIFTINDLQLD
DVATYYCQVIESFGQGTRLDINRTVAAPSVFIFPPSDEQL
KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE
QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPV
TKSFNRGE
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Description
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