eF-site ID 4yal-AB PDB Code 4yal Chain A, B click to enlarge Title Reduced CYPOR with 2'-AMP Classification OXIDOREDUCTASE Compound NADPH--cytochrome P450 reductase Source (NCPR_RAT) Sequence A:  PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKD AHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYG EGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHF NAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWRE QFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGR LKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLEL DISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVI MSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNV LYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARR HILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVH PNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVP MFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWL REQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQ LNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVC GDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKG RYSLDVWS B:  PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKD AHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYG EGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHF NAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWRE QFWPAVCEFFGVEATIRQYELVVHEDMDVAKVYTGEMGRL KSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELD ISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIM SLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVL YELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRH ILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHP NSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVP MFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWL REQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQ LNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVC GDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKG RYSLDVWS Description Functional site 1) chain A residue 86 type sequence S description binding site for residue FMN A 701 source : AC1 2) chain A residue 87 type sequence Q description binding site for residue FMN A 701 source : AC1 3) chain A residue 88 type sequence T description binding site for residue FMN A 701 source : AC1 4) chain A residue 89 type sequence G description binding site for residue FMN A 701 source : AC1 5) chain A residue 90 type sequence T description binding site for residue FMN A 701 source : AC1 6) chain A residue 91 type sequence A description binding site for residue FMN A 701 source : AC1 7) chain A residue 138 type sequence A description binding site for residue FMN A 701 source : AC1 8) chain A residue 139 type sequence T description binding site for residue FMN A 701 source : AC1 9) chain A residue 140 type sequence Y description binding site for residue FMN A 701 source : AC1 10) chain A residue 141 type sequence G description binding site for residue FMN A 701 source : AC1 11) chain A residue 143 type sequence G description binding site for residue FMN A 701 source : AC1 12) chain A residue 173 type sequence L description binding site for residue FMN A 701 source : AC1 13) chain A residue 174 type sequence G description binding site for residue FMN A 701 source : AC1 14) chain A residue 175 type sequence N description binding site for residue FMN A 701 source : AC1 15) chain A residue 178 type sequence Y description binding site for residue FMN A 701 source : AC1 16) chain A residue 180 type sequence H description binding site for residue FMN A 701 source : AC1 17) chain A residue 181 type sequence F description binding site for residue FMN A 701 source : AC1 18) chain A residue 182 type sequence N description binding site for residue FMN A 701 source : AC1 19) chain A residue 208 type sequence D description binding site for residue FMN A 701 source : AC1 20) chain A residue 212 type sequence L description binding site for residue FMN A 701 source : AC1 21) chain A residue 319 type sequence H description binding site for residue FAD A 702 source : AC2 22) chain A residue 424 type sequence R description binding site for residue FAD A 702 source : AC2 23) chain A residue 454 type sequence R description binding site for residue FAD A 702 source : AC2 24) chain A residue 455 type sequence Y description binding site for residue FAD A 702 source : AC2 25) chain A residue 456 type sequence Y description binding site for residue FAD A 702 source : AC2 26) chain A residue 457 type sequence S description binding site for residue FAD A 702 source : AC2 27) chain A residue 472 type sequence C description binding site for residue FAD A 702 source : AC2 28) chain A residue 473 type sequence A description binding site for residue FAD A 702 source : AC2 29) chain A residue 474 type sequence V description binding site for residue FAD A 702 source : AC2 30) chain A residue 478 type sequence Y description binding site for residue FAD A 702 source : AC2 31) chain A residue 488 type sequence G description binding site for residue FAD A 702 source : AC2 32) chain A residue 489 type sequence V description binding site for residue FAD A 702 source : AC2 33) chain A residue 490 type sequence A description binding site for residue FAD A 702 source : AC2 34) chain A residue 491 type sequence T description binding site for residue FAD A 702 source : AC2 35) chain A residue 677 type sequence W description binding site for residue FAD A 702 source : AC2 36) chain A residue 566 type sequence C description binding site for residue 2AM A 703 source : AC3 37) chain A residue 567 type sequence R description binding site for residue 2AM A 703 source : AC3 38) chain A residue 596 type sequence S description binding site for residue 2AM A 703 source : AC3 39) chain A residue 597 type sequence R description binding site for residue 2AM A 703 source : AC3 40) chain A residue 602 type sequence K description binding site for residue 2AM A 703 source : AC3 41) chain A residue 604 type sequence Y description binding site for residue 2AM A 703 source : AC3 42) chain A residue 606 type sequence Q description binding site for residue 2AM A 703 source : AC3 43) chain A residue 635 type sequence N description binding site for residue 2AM A 703 source : AC3 44) chain A residue 636 type sequence M description binding site for residue 2AM A 703 source : AC3 45) chain A residue 639 type sequence D description binding site for residue 2AM A 703 source : AC3 46) chain A residue 293 type sequence N description binding site for residue PO4 A 704 source : AC4 47) chain A residue 295 type sequence G description binding site for residue PO4 A 704 source : AC4 48) chain A residue 296 type sequence T description binding site for residue PO4 A 704 source : AC4 49) chain A residue 297 type sequence E description binding site for residue PO4 A 704 source : AC4 50) chain A residue 298 type sequence R description binding site for residue PO4 A 704 source : AC4 51) chain A residue 567 type sequence R description binding site for residue PO4 A 704 source : AC4 52) chain A residue 465 type sequence H description binding site for residue PO4 A 705 source : AC5 53) chain A residue 466 type sequence P description binding site for residue PO4 A 705 source : AC5 54) chain A residue 467 type sequence N description binding site for residue PO4 A 705 source : AC5 55) chain A residue 468 type sequence S description binding site for residue PO4 A 705 source : AC5 56) chain B residue 86 type sequence S description binding site for residue FMN B 701 source : AC6 57) chain B residue 87 type sequence Q description binding site for residue FMN B 701 source : AC6 58) chain B residue 88 type sequence T description binding site for residue FMN B 701 source : AC6 59) chain B residue 89 type sequence G description binding site for residue FMN B 701 source : AC6 60) chain B residue 90 type sequence T description binding site for residue FMN B 701 source : AC6 61) chain B residue 91 type sequence A description binding site for residue FMN B 701 source : AC6 62) chain B residue 138 type sequence A description binding site for residue FMN B 701 source : AC6 63) chain B residue 139 type sequence T description binding site for residue FMN B 701 source : AC6 64) chain B residue 140 type sequence Y description binding site for residue FMN B 701 source : AC6 65) chain B residue 141 type sequence G description binding site for residue FMN B 701 source : AC6 66) chain B residue 142 type sequence E description binding site for residue FMN B 701 source : AC6 67) chain B residue 143 type sequence G description binding site for residue FMN B 701 source : AC6 68) chain B residue 173 type sequence L description binding site for residue FMN B 701 source : AC6 69) chain B residue 174 type sequence G description binding site for residue FMN B 701 source : AC6 70) chain B residue 175 type sequence N description binding site for residue FMN B 701 source : AC6 71) chain B residue 178 type sequence Y description binding site for residue FMN B 701 source : AC6 72) chain B residue 180 type sequence H description binding site for residue FMN B 701 source : AC6 73) chain B residue 181 type sequence F description binding site for residue FMN B 701 source : AC6 74) chain B residue 182 type sequence N description binding site for residue FMN B 701 source : AC6 75) chain B residue 208 type sequence D description binding site for residue FMN B 701 source : AC6 76) chain B residue 212 type sequence L description binding site for residue FMN B 701 source : AC6 77) chain B residue 319 type sequence H description binding site for residue FAD B 702 source : AC7 78) chain B residue 424 type sequence R description binding site for residue FAD B 702 source : AC7 79) chain B residue 454 type sequence R description binding site for residue FAD B 702 source : AC7 80) chain B residue 455 type sequence Y description binding site for residue FAD B 702 source : AC7 81) chain B residue 456 type sequence Y description binding site for residue FAD B 702 source : AC7 82) chain B residue 457 type sequence S description binding site for residue FAD B 702 source : AC7 83) chain B residue 472 type sequence C description binding site for residue FAD B 702 source : AC7 84) chain B residue 473 type sequence A description binding site for residue FAD B 702 source : AC7 85) chain B residue 474 type sequence V description binding site for residue FAD B 702 source : AC7 86) chain B residue 478 type sequence Y description binding site for residue FAD B 702 source : AC7 87) chain B residue 488 type sequence G description binding site for residue FAD B 702 source : AC7 88) chain B residue 489 type sequence V description binding site for residue FAD B 702 source : AC7 89) chain B residue 490 type sequence A description binding site for residue FAD B 702 source : AC7 90) chain B residue 491 type sequence T description binding site for residue FAD B 702 source : AC7 91) chain B residue 677 type sequence W description binding site for residue FAD B 702 source : AC7 92) chain B residue 566 type sequence C description binding site for residue 2AM B 703 source : AC8 93) chain B residue 567 type sequence R description binding site for residue 2AM B 703 source : AC8 94) chain B residue 596 type sequence S description binding site for residue 2AM B 703 source : AC8 95) chain B residue 597 type sequence R description binding site for residue 2AM B 703 source : AC8 96) chain B residue 602 type sequence K description binding site for residue 2AM B 703 source : AC8 97) chain B residue 604 type sequence Y description binding site for residue 2AM B 703 source : AC8 98) chain B residue 606 type sequence Q description binding site for residue 2AM B 703 source : AC8 99) chain B residue 635 type sequence N description binding site for residue 2AM B 703 source : AC8 100) chain B residue 636 type sequence M description binding site for residue 2AM B 703 source : AC8 101) chain B residue 639 type sequence D description binding site for residue 2AM B 703 source : AC8 102) chain B residue 293 type sequence N description binding site for residue PO4 B 704 source : AC9 103) chain B residue 295 type sequence G description binding site for residue PO4 B 704 source : AC9 104) chain B residue 296 type sequence T description binding site for residue PO4 B 704 source : AC9 105) chain B residue 297 type sequence E description binding site for residue PO4 B 704 source : AC9 106) chain B residue 298 type sequence R description binding site for residue PO4 B 704 source : AC9 107) chain B residue 567 type sequence R description binding site for residue PO4 B 704 source : AC9 108) chain B residue 571 type sequence E description binding site for residue PO4 B 704 source : AC9 109) chain B residue 465 type sequence H description binding site for residue PO4 B 705 source : AD1 110) chain B residue 466 type sequence P description binding site for residue PO4 B 705 source : AD1 111) chain B residue 467 type sequence N description binding site for residue PO4 B 705 source : AD1 112) chain B residue 468 type sequence S description binding site for residue PO4 B 705 source : AD1 113) chain A residue 457 type catalytic sequence S description 117 source MCSA : MCSA1 114) chain A residue 630 type catalytic sequence C description 117 source MCSA : MCSA1 115) chain A residue 675 type catalytic sequence D description 117 source MCSA : MCSA1 116) chain A residue 677 type catalytic sequence W description 117 source MCSA : MCSA1 117) chain B residue 457 type catalytic sequence S description 117 source MCSA : MCSA2 118) chain B residue 630 type catalytic sequence C description 117 source MCSA : MCSA2 119) chain B residue 675 type catalytic sequence D description 117 source MCSA : MCSA2 120) chain B residue 677 type catalytic sequence W description 117 source MCSA : MCSA2 121) chain A residue 86 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 122) chain A residue 677 type BINDING sequence W description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 123) chain B residue 86 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 124) chain B residue 138 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 125) chain B residue 173 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 126) chain B residue 454 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 127) chain B residue 478 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 128) chain B residue 488 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 129) chain B residue 535 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 130) chain B residue 596 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 131) chain B residue 602 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 132) chain A residue 138 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 133) chain B residue 677 type BINDING sequence W description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 134) chain A residue 173 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 135) chain A residue 454 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 136) chain A residue 478 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 137) chain A residue 488 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 138) chain A residue 535 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 139) chain A residue 596 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 140) chain A residue 602 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI1 141) chain A residue 208 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI2 142) chain B residue 208 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI2 143) chain A residue 298 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI3 144) chain A residue 639 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI3 145) chain B residue 298 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI3 146) chain B residue 639 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 source Swiss-Prot : SWS_FT_FI3 147) chain A residue 424 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI4 148) chain B residue 424 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI4 149) chain A residue 472 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI5 150) chain B residue 472 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 source Swiss-Prot : SWS_FT_FI5

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