eF-site ID 4y7w-b
PDB Code 4y7w
Chain b

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Title Yeast 20S proteasome in complex with Ac-LAE-ep
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae;
Sequence b:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
Description


Functional site

1) chain b
residue 1
type
sequence T
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

2) chain b
residue 19
type
sequence R
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

3) chain b
residue 20
type
sequence T
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

4) chain b
residue 21
type
sequence T
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

5) chain b
residue 31
type
sequence T
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

6) chain b
residue 45
type
sequence R
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

7) chain b
residue 47
type
sequence G
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

8) chain b
residue 49
type
sequence A
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

9) chain b
residue 129
type
sequence S
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

10) chain b
residue 168
type
sequence S
description binding site for Ligand residues POL h 5 through ALA h 3 bound to THR b 1
source : AE6

11) chain b
residue 1
type
sequence T
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

12) chain b
residue 20
type
sequence T
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

13) chain b
residue 31
type
sequence T
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

14) chain b
residue 45
type
sequence R
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

15) chain b
residue 47
type
sequence G
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

16) chain b
residue 49
type
sequence A
description binding site for Ligand GAU h 4 bound to THR b 1
source : AE7

17) chain b
residue 21
type
sequence T
description binding site for Di-peptide ACE h 1 and LEU h 2
source : AF4

18) chain b
residue 48
type
sequence S
description binding site for Di-peptide ACE h 1 and LEU h 2
source : AF4

19) chain b
residue 49
type
sequence A
description binding site for Di-peptide ACE h 1 and LEU h 2
source : AF4

20) chain b
residue 1
type ACT_SITE
sequence T
description Nucleophile => ECO:0000269|PubMed:9087403
source Swiss-Prot : SWS_FT_FI1

21) chain b
residue 4-51
type prosite
sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC
CRSGSAAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD
source prosite : PS00854


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