eF-site ID 4y6g-B PDB Code 4y6g Chain B click to enlarge Title Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site. Classification LYASE/LYASE INHIBITOR Compound Tryptophan synthase alpha chain Source (TRPB_SALTY) Sequence B:  TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEF QAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLL HGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASAL ASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHS GSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIV REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMF ADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFG MKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGR ADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKM MREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI Description Functional site 1) chain B residue 18 type sequence P description binding site for residue F6F A 301 source : AC1 2) chain B residue 86 type sequence H description binding site for residue PLP B 401 source : AC2 3) chain B residue 87 type sequence K description binding site for residue PLP B 401 source : AC2 4) chain B residue 114 type sequence Q description binding site for residue PLP B 401 source : AC2 5) chain B residue 190 type sequence T description binding site for residue PLP B 401 source : AC2 6) chain B residue 230 type sequence C description binding site for residue PLP B 401 source : AC2 7) chain B residue 232 type sequence G description binding site for residue PLP B 401 source : AC2 8) chain B residue 233 type sequence G description binding site for residue PLP B 401 source : AC2 9) chain B residue 234 type sequence G description binding site for residue PLP B 401 source : AC2 10) chain B residue 235 type sequence S description binding site for residue PLP B 401 source : AC2 11) chain B residue 236 type sequence N description binding site for residue PLP B 401 source : AC2 12) chain B residue 303 type sequence G description binding site for residue PLP B 401 source : AC2 13) chain B residue 350 type sequence E description binding site for residue PLP B 401 source : AC2 14) chain B residue 377 type sequence S description binding site for residue PLP B 401 source : AC2 15) chain B residue 378 type sequence G description binding site for residue PLP B 401 source : AC2 16) chain B residue 87 type sequence K description binding site for residue F6F B 402 source : AC3 17) chain B residue 109 type sequence E description binding site for residue F6F B 402 source : AC3 18) chain B residue 110 type sequence T description binding site for residue F6F B 402 source : AC3 19) chain B residue 111 type sequence G description binding site for residue F6F B 402 source : AC3 20) chain B residue 112 type sequence A description binding site for residue F6F B 402 source : AC3 21) chain B residue 113 type sequence G description binding site for residue F6F B 402 source : AC3 22) chain B residue 114 type sequence Q description binding site for residue F6F B 402 source : AC3 23) chain B residue 115 type sequence H description binding site for residue F6F B 402 source : AC3 24) chain B residue 170 type sequence C description binding site for residue F6F B 402 source : AC3 25) chain B residue 174 type sequence L description binding site for residue F6F B 402 source : AC3 26) chain B residue 186 type sequence Y description binding site for residue F6F B 402 source : AC3 27) chain B residue 188 type sequence L description binding site for residue F6F B 402 source : AC3 28) chain B residue 190 type sequence T description binding site for residue F6F B 402 source : AC3 29) chain B residue 193 type sequence G description binding site for residue F6F B 402 source : AC3 30) chain B residue 280 type sequence F description binding site for residue F6F B 402 source : AC3 31) chain B residue 306 type sequence F description binding site for residue F6F B 402 source : AC3 32) chain B residue 232 type sequence G description binding site for residue NA B 403 source : AC4 33) chain B residue 306 type sequence F description binding site for residue NA B 403 source : AC4 34) chain B residue 308 type sequence S description binding site for residue NA B 403 source : AC4 35) chain B residue 87 type catalytic sequence K description 383 source MCSA : MCSA1 36) chain B residue 109 type catalytic sequence E description 383 source MCSA : MCSA1 37) chain B residue 377 type catalytic sequence S description 383 source MCSA : MCSA1 38) chain B residue 80-94 type prosite sequence LLHGGAHKTNQVLGQ description TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ source prosite : PS00168 39) chain B residue 87 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1

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