eF-site ID 4y6g-AB PDB Code 4y6g Chain A, B click to enlarge Title Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site. Classification LYASE/LYASE INHIBITOR Compound Tryptophan synthase alpha chain Source (TRPB_SALTY) Sequence A:  MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTL IDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQ CFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQ VGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADD DLLRQVASYGRGYTYLLSRSGLHHLIEKLKEYHAAPALQG FGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQM LAELRSFVSAMKAASRA B:  TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEF QAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLL HGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASAL ASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHS GSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIV REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMF ADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFG MKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGR ADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKM MREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI Description Functional site 1) chain A residue 49 type sequence E description binding site for residue F6F A 301 source : AC1 2) chain A residue 59 type sequence A description binding site for residue F6F A 301 source : AC1 3) chain A residue 60 type sequence D description binding site for residue F6F A 301 source : AC1 4) chain A residue 64 type sequence I description binding site for residue F6F A 301 source : AC1 5) chain A residue 100 type sequence L description binding site for residue F6F A 301 source : AC1 6) chain A residue 127 type sequence L description binding site for residue F6F A 301 source : AC1 7) chain A residue 129 type sequence A description binding site for residue F6F A 301 source : AC1 8) chain A residue 153 type sequence I description binding site for residue F6F A 301 source : AC1 9) chain A residue 175 type sequence Y description binding site for residue F6F A 301 source : AC1 10) chain A residue 212 type sequence F description binding site for residue F6F A 301 source : AC1 11) chain A residue 213 type sequence G description binding site for residue F6F A 301 source : AC1 12) chain A residue 234 type sequence G description binding site for residue F6F A 301 source : AC1 13) chain A residue 235 type sequence S description binding site for residue F6F A 301 source : AC1 14) chain B residue 18 type sequence P description binding site for residue F6F A 301 source : AC1 15) chain B residue 86 type sequence H description binding site for residue PLP B 401 source : AC2 16) chain B residue 87 type sequence K description binding site for residue PLP B 401 source : AC2 17) chain B residue 114 type sequence Q description binding site for residue PLP B 401 source : AC2 18) chain B residue 190 type sequence T description binding site for residue PLP B 401 source : AC2 19) chain B residue 230 type sequence C description binding site for residue PLP B 401 source : AC2 20) chain B residue 232 type sequence G description binding site for residue PLP B 401 source : AC2 21) chain B residue 233 type sequence G description binding site for residue PLP B 401 source : AC2 22) chain B residue 234 type sequence G description binding site for residue PLP B 401 source : AC2 23) chain B residue 235 type sequence S description binding site for residue PLP B 401 source : AC2 24) chain B residue 236 type sequence N description binding site for residue PLP B 401 source : AC2 25) chain B residue 303 type sequence G description binding site for residue PLP B 401 source : AC2 26) chain B residue 350 type sequence E description binding site for residue PLP B 401 source : AC2 27) chain B residue 377 type sequence S description binding site for residue PLP B 401 source : AC2 28) chain B residue 378 type sequence G description binding site for residue PLP B 401 source : AC2 29) chain B residue 87 type sequence K description binding site for residue F6F B 402 source : AC3 30) chain B residue 109 type sequence E description binding site for residue F6F B 402 source : AC3 31) chain B residue 110 type sequence T description binding site for residue F6F B 402 source : AC3 32) chain B residue 111 type sequence G description binding site for residue F6F B 402 source : AC3 33) chain B residue 112 type sequence A description binding site for residue F6F B 402 source : AC3 34) chain B residue 113 type sequence G description binding site for residue F6F B 402 source : AC3 35) chain B residue 114 type sequence Q description binding site for residue F6F B 402 source : AC3 36) chain B residue 115 type sequence H description binding site for residue F6F B 402 source : AC3 37) chain B residue 170 type sequence C description binding site for residue F6F B 402 source : AC3 38) chain B residue 174 type sequence L description binding site for residue F6F B 402 source : AC3 39) chain B residue 186 type sequence Y description binding site for residue F6F B 402 source : AC3 40) chain B residue 188 type sequence L description binding site for residue F6F B 402 source : AC3 41) chain B residue 190 type sequence T description binding site for residue F6F B 402 source : AC3 42) chain B residue 193 type sequence G description binding site for residue F6F B 402 source : AC3 43) chain B residue 280 type sequence F description binding site for residue F6F B 402 source : AC3 44) chain B residue 306 type sequence F description binding site for residue F6F B 402 source : AC3 45) chain B residue 232 type sequence G description binding site for residue NA B 403 source : AC4 46) chain B residue 306 type sequence F description binding site for residue NA B 403 source : AC4 47) chain B residue 308 type sequence S description binding site for residue NA B 403 source : AC4 48) chain B residue 80-94 type prosite sequence LLHGGAHKTNQVLGQ description TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ source prosite : PS00168 49) chain A residue 48-61 type prosite sequence LELGVPFSDPLADG description TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG source prosite : PS00167 50) chain B residue 87 type catalytic sequence K description 383 source MCSA : MCSA1 51) chain B residue 109 type catalytic sequence E description 383 source MCSA : MCSA1 52) chain B residue 377 type catalytic sequence S description 383 source MCSA : MCSA1 53) chain B residue 87 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1 54) chain A residue 60 type MOD_RES sequence D description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1

Display surface Download Links