eF-site ID 4y6g-A PDB Code 4y6g Chain A click to enlarge Title Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site. Classification LYASE/LYASE INHIBITOR Compound Tryptophan synthase alpha chain Source (TRPB_SALTY) Sequence A:  MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTL IDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQ CFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQ VGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADD DLLRQVASYGRGYTYLLSRSGLHHLIEKLKEYHAAPALQG FGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQM LAELRSFVSAMKAASRA Description Functional site 1) chain A residue 49 type sequence E description binding site for residue F6F A 301 source : AC1 2) chain A residue 59 type sequence A description binding site for residue F6F A 301 source : AC1 3) chain A residue 60 type sequence D description binding site for residue F6F A 301 source : AC1 4) chain A residue 64 type sequence I description binding site for residue F6F A 301 source : AC1 5) chain A residue 100 type sequence L description binding site for residue F6F A 301 source : AC1 6) chain A residue 127 type sequence L description binding site for residue F6F A 301 source : AC1 7) chain A residue 129 type sequence A description binding site for residue F6F A 301 source : AC1 8) chain A residue 153 type sequence I description binding site for residue F6F A 301 source : AC1 9) chain A residue 175 type sequence Y description binding site for residue F6F A 301 source : AC1 10) chain A residue 212 type sequence F description binding site for residue F6F A 301 source : AC1 11) chain A residue 213 type sequence G description binding site for residue F6F A 301 source : AC1 12) chain A residue 234 type sequence G description binding site for residue F6F A 301 source : AC1 13) chain A residue 235 type sequence S description binding site for residue F6F A 301 source : AC1 14) chain A residue 48-61 type prosite sequence LELGVPFSDPLADG description TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG source prosite : PS00167 15) chain A residue 60 type MOD_RES sequence D description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1

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