eF-site ID 4y67-B PDB Code 4y67 Chain B click to enlarge Title Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC176, and manganese Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast Source Plasmodium falciparum (isolate 3D7) (DXR_PLAF7) Sequence B:  PINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNK SVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKP IILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMN NKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSA IFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQN LTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEV IETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMY YPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSL EHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIK YFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKD KATDIYNKHN Description Functional site 1) chain B residue 205 type sequence K description binding site for residue RC5 B 501 source : AC3 2) chain B residue 231 type sequence D description binding site for residue RC5 B 501 source : AC3 3) chain B residue 232 type sequence S description binding site for residue RC5 B 501 source : AC3 4) chain B residue 233 type sequence E description binding site for residue RC5 B 501 source : AC3 5) chain B residue 269 type sequence S description binding site for residue RC5 B 501 source : AC3 6) chain B residue 270 type sequence S description binding site for residue RC5 B 501 source : AC3 7) chain B residue 296 type sequence W description binding site for residue RC5 B 501 source : AC3 8) chain B residue 306 type sequence S description binding site for residue RC5 B 501 source : AC3 9) chain B residue 311 type sequence N description binding site for residue RC5 B 501 source : AC3 10) chain B residue 312 type sequence K description binding site for residue RC5 B 501 source : AC3 11) chain B residue 315 type sequence E description binding site for residue RC5 B 501 source : AC3 12) chain B residue 341 type sequence H description binding site for residue RC5 B 501 source : AC3 13) chain B residue 359 type sequence D description binding site for residue RC5 B 501 source : AC3 14) chain B residue 205 type sequence K description binding site for residue MN B 502 source : AC4 15) chain B residue 231 type sequence D description binding site for residue MN B 502 source : AC4 16) chain B residue 233 type sequence E description binding site for residue MN B 502 source : AC4 17) chain B residue 315 type sequence E description binding site for residue MN B 502 source : AC4 18) chain B residue 270 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 293 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 306 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 311 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 312 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 205 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 232 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 86 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 115 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 206 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 299 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 231 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 233 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 315 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links