eF-site ID 4y67-A PDB Code 4y67 Chain A click to enlarge Title Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC176, and manganese Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast Source Plasmodium falciparum (isolate 3D7) (DXR_PLAF7) Sequence A:  PINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNK SVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKP IILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMN NKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSA IFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQN LTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEV IETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMY YPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSL EHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIK YFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKD KATDIYNKHN Description Functional site 1) chain A residue 205 type sequence K description binding site for residue RC5 A 501 source : AC1 2) chain A residue 231 type sequence D description binding site for residue RC5 A 501 source : AC1 3) chain A residue 232 type sequence S description binding site for residue RC5 A 501 source : AC1 4) chain A residue 233 type sequence E description binding site for residue RC5 A 501 source : AC1 5) chain A residue 269 type sequence S description binding site for residue RC5 A 501 source : AC1 6) chain A residue 270 type sequence S description binding site for residue RC5 A 501 source : AC1 7) chain A residue 296 type sequence W description binding site for residue RC5 A 501 source : AC1 8) chain A residue 306 type sequence S description binding site for residue RC5 A 501 source : AC1 9) chain A residue 311 type sequence N description binding site for residue RC5 A 501 source : AC1 10) chain A residue 312 type sequence K description binding site for residue RC5 A 501 source : AC1 11) chain A residue 315 type sequence E description binding site for residue RC5 A 501 source : AC1 12) chain A residue 341 type sequence H description binding site for residue RC5 A 501 source : AC1 13) chain A residue 359 type sequence D description binding site for residue RC5 A 501 source : AC1 14) chain A residue 205 type sequence K description binding site for residue MN A 502 source : AC2 15) chain A residue 231 type sequence D description binding site for residue MN A 502 source : AC2 16) chain A residue 233 type sequence E description binding site for residue MN A 502 source : AC2 17) chain A residue 315 type sequence E description binding site for residue MN A 502 source : AC2 18) chain A residue 86 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 115 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 206 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 299 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:O96693 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 205 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 232 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 270 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 293 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 306 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 311 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 312 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P45568 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 231 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 233 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 315 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25781377, ECO:0000269|PubMed:27487410, ECO:0007744|PDB:4Y67, ECO:0007744|PDB:4Y6P, ECO:0007744|PDB:4Y6R, ECO:0007744|PDB:4Y6S, ECO:0007744|PDB:5JAZ, ECO:0007744|PDB:5JBI, ECO:0007744|PDB:5JC1, ECO:0007744|PDB:5JMP, ECO:0007744|PDB:5JMW, ECO:0007744|PDB:5JNL, ECO:0007744|PDB:5JO0 source Swiss-Prot : SWS_FT_FI3

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