eF-site ID 4y2a-A PDB Code 4y2a Chain A click to enlarge Title Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound 3D polymerase Source Coxsackievirus B3 (strain Nancy) (POLG_CXB3N) Sequence A:  GEIEFIESSKDAGFPVINTPSKTKLEPSVFHQVFEGNKEP AVLRSGDPRLKANFEEAIFSKYIGNVNTHVDEYMLEAVDH YAGQLATLDISTEPMKLEDAVYGTEGLEALDLTTSAGYPY VALGIKKRDILSKKTKDLTKLKECMDKYGLNLPMVTYVKD ELRSIEKVAKGKSRLIEASSLNDSVAMRQTFGNLYKTFHL NPGVVTGSAVGCDPDLFWSKIPVMLDGHLIAFDYSGYDAS LSPVWFACLKMLLEKLGYTHKETNYIDYLCNSHHLYRDKH YFVRGGMPSGCSGTSIFNSMINNIIIRTLMLKVYKGIDLD QFRMIAYGDDVIASYPWPIDASLLAEAGKGYGLIMTPADK GECFNEVTWTNATFLKRYFRADEQYPFLVHPVMPMKDIHE SIRWTKDPKNTQDHVRSLCLLAWHNGEHEYEEFIRKIRSV PVGRCLTLPAFSTLRRKWLDSFHHHH Description Functional site 1) chain A residue 107 type sequence L description binding site for residue 1FS A 501 source : AC1 2) chain A residue 108 type sequence E description binding site for residue 1FS A 501 source : AC1 3) chain A residue 111 type sequence D description binding site for residue 1FS A 501 source : AC1 4) chain A residue 184 type sequence S description binding site for residue 1FS A 501 source : AC1 5) chain A residue 188 type sequence R description binding site for residue 1FS A 501 source : AC1 6) chain A residue 199 type sequence H description binding site for residue 1FS A 501 source : AC1 7) chain A residue 290 type sequence G description binding site for residue 1FS A 501 source : AC1 8) chain A residue 291 type sequence C description binding site for residue 1FS A 501 source : AC1 9) chain A residue 292 type sequence S description binding site for residue 1FS A 501 source : AC1 10) chain A residue 293 type sequence G description binding site for residue 1FS A 501 source : AC1 11) chain A residue 294 type sequence T description binding site for residue 1FS A 501 source : AC1 12) chain A residue 295 type sequence S description binding site for residue 1FS A 501 source : AC1 13) chain A residue 296 type sequence I description binding site for residue 1FS A 501 source : AC1 14) chain A residue 327 type sequence Y description binding site for residue 1FS A 501 source : AC1 15) chain A residue 61 type sequence K description binding site for residue SO4 A 502 source : AC2 16) chain A residue 174 type sequence R description binding site for residue SO4 A 502 source : AC2 17) chain A residue 236 type sequence G description binding site for residue SO4 A 502 source : AC2 18) chain A residue 416 type sequence R description binding site for residue SO4 A 503 source : AC3 19) chain A residue 449 type sequence P description binding site for residue SO4 A 503 source : AC3 20) chain A residue 453 type sequence T description binding site for residue SO4 A 503 source : AC3 21) chain A residue 384 type sequence Q description binding site for residue SO4 A 504 source : AC4 22) chain A residue 385 type sequence Y description binding site for residue SO4 A 504 source : AC4 23) chain A residue 409 type sequence K description binding site for residue SO4 A 504 source : AC4 24) chain A residue 455 type sequence R description binding site for residue SO4 A 504 source : AC4 25) chain A residue 38 type sequence K description binding site for residue SO4 A 505 source : AC5 26) chain A residue 376 type sequence K description binding site for residue SO4 A 505 source : AC5 27) chain A residue 397 type sequence D description binding site for residue SO4 A 505 source : AC5 28) chain A residue 400 type sequence E description binding site for residue SO4 A 505 source : AC5 29) chain A residue 426 type sequence G description binding site for residue SO4 A 506 source : AC6 30) chain A residue 427 type sequence E description binding site for residue SO4 A 506 source : AC6 31) chain A residue 428 type sequence H description binding site for residue SO4 A 506 source : AC6 32) chain A residue 406 type sequence K description binding site for residue GOL A 507 source : AC7 33) chain A residue 414 type sequence H description binding site for residue GOL A 507 source : AC7 34) chain A residue 385 type sequence Y description binding site for residue GOL A 508 source : AC8 35) chain A residue 388 type sequence L description binding site for residue GOL A 508 source : AC8 36) chain A residue 408 type sequence P description binding site for residue GOL A 508 source : AC8 37) chain A residue 459 type sequence L description binding site for residue GOL A 508 source : AC8 38) chain A residue 463 type sequence H description binding site for residue GOL A 508 source : AC8 39) chain A residue 44 type sequence R description binding site for residue GOL A 509 source : AC9 40) chain A residue 45 type sequence S description binding site for residue GOL A 509 source : AC9 41) chain A residue 46 type sequence G description binding site for residue GOL A 509 source : AC9 42) chain A residue 38 type sequence K description binding site for residue GOL A 510 source : AD1 43) chain A residue 163 type sequence R description binding site for residue GOL A 510 source : AD1 44) chain A residue 164 type sequence S description binding site for residue GOL A 510 source : AD1 45) chain A residue 167 type sequence K description binding site for residue GOL A 510 source : AD1 46) chain A residue 174 type sequence R description binding site for residue GOL A 510 source : AD1 47) chain A residue 233 type BINDING sequence D description BINDING => ECO:0000305|PubMed:23667424 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 329 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P03300 source Swiss-Prot : SWS_FT_FI2

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