eF-site ID 4xwk-A PDB Code 4xwk Chain A click to enlarge Title P-glycoprotein co-crystallized with BDE-100 Classification HYDROLASE Compound Multidrug resistance protein 1A Source (MDR1A_MOUSE) Sequence A:  KPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMML IFGDMTDSFASVGQVSKQSTQMSEADKRAMFAKLEEEMTT YAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFH AIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMF FQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWA KILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKE LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALA FWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIE AFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLE FKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGK STTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVV SQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFI MKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL LDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVR NADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTPPA SFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKV VGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGF TFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALT TRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGW QLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGK IATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKA HVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVL LVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKT PEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQG LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVF LDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD NSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQ LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQ EALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHG THQQLLAQKGIYFSMVSVQAGA Description Functional site 1) chain A residue 331 type sequence F description binding site for residue 4C8 A 1301 source : AC1 2) chain A residue 724 type sequence F description binding site for residue 4C8 A 1301 source : AC1 3) chain A residue 727 type sequence I description binding site for residue 4C8 A 1301 source : AC1 4) chain A residue 728 type sequence F description binding site for residue 4C8 A 1301 source : AC1 5) chain A residue 755 type sequence F description binding site for residue 4C8 A 1301 source : AC1 6) chain A residue 979 type sequence F description binding site for residue 4C8 A 1301 source : AC1 7) chain A residue 134-182 type TOPO_DOM sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD DVSKINEGI description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 233-290 type TOPO_DOM sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAIT description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 349-707 type TOPO_DOM sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTPP ASFWRILKLNSTEWPYF description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 774-828 type TOPO_DOM sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR LANDAAQVKGATGSR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 871-930 type TOPO_DOM sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ KFETMYAQSLQIPYRNAMKK description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 67-112 type TOPO_DOM sequence MMLIFGDMTDSFASVGQVSKQSTQMSEADKRAMFAKLEEE MTTYAY description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 205-211 type TOPO_DOM sequence TRGWKLT description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 313-326 type TOPO_DOM sequence GTSLVISKEYSIGQ description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 729-752 type TOPO_DOM sequence SKVVGVFTNGGPPETQRQNSNLFS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 954-969 type TOPO_DOM sequence RFGAYLVTQQLMTFEN description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 850 type TOPO_DOM sequence G description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 1066 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 423 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 87 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 21) chain A residue 90 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 22) chain A residue 83 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 23) chain A residue 527-541 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 24) chain A residue 1172-1186 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 25) chain A residue 44-66 type TRANSMEM sequence WLDRLYMLVGTLAAIIHGVALPL description Helical source Swiss-Prot : SWS_FT_FI2 26) chain A residue 113-133 type TRANSMEM sequence YYTGIGAGVLIVAYIQVSFWC description Helical source Swiss-Prot : SWS_FT_FI2 27) chain A residue 183-204 type TRANSMEM sequence GDKIGMFFQAMATFFGGFIIGF description Helical source Swiss-Prot : SWS_FT_FI2 28) chain A residue 212-232 type TRANSMEM sequence LVILAISPVLGLSAGIWAKIL description Helical source Swiss-Prot : SWS_FT_FI2 29) chain A residue 291-312 type TRANSMEM sequence ANISMGAAFLLIYASYALAFWY description Helical source Swiss-Prot : SWS_FT_FI2 30) chain A residue 327-348 type TRANSMEM sequence VLTVFFSVLIGAFSVGQASPNI description Helical source Swiss-Prot : SWS_FT_FI2 31) chain A residue 708-728 type TRANSMEM sequence VVGIFCAIINGGLQPAFSVIF description Helical source Swiss-Prot : SWS_FT_FI2 32) chain A residue 753-773 type TRANSMEM sequence LLFLILGIISFITFFLQGFTF description Helical source Swiss-Prot : SWS_FT_FI2 33) chain A residue 829-849 type TRANSMEM sequence LAVIFQNIANLGTGIIISLIY description Helical source Swiss-Prot : SWS_FT_FI2 34) chain A residue 851-870 type TRANSMEM sequence WQLTLLLLAIVPIIAIAGVV description Helical source Swiss-Prot : SWS_FT_FI2 35) chain A residue 931-953 type TRANSMEM sequence AHVFGITFSFTQAMMYFSYAACF description Helical source Swiss-Prot : SWS_FT_FI2 36) chain A residue 970-991 type TRANSMEM sequence VLLVFSAIVFGAMAVGQVSSFA description Helical source Swiss-Prot : SWS_FT_FI2

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