eF-site ID 4xvc-ABCDEFGH PDB Code 4xvc Chain A, B, C, D, E, F, G, H click to enlarge Title Crystal structure of an esterase from the bacterial hormone-sensitive lipase (HSL) family Classification HYDROLASE Compound Esterase E40 Source (4XVC) Sequence A:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG B:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG C:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG D:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG E:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG F:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG G:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG H:  MAKSPELDRVIGMIRERAATPRKTTDDDRRLYETMLGSMP LDDDIQTERLGVNGVPAEWIYAPGARDDQVFLYLHGGGYV IGSMRTHRVMLSHIARAAGCRVLGLDYRLAPETPFPAPVE DTVAAYRWLLAHGYDPSRIALGGDSAGGGLVVAALVALRY IGEPLPAAGVCLSPWIDMEATGESFTTNATMDPSVNKERV MSIAALYLGGKNPQAPLASPLYADLQGLPPLLVQVGGIET LLDDARALTTRAKAAGVDADLEVWDDMPHVWQHFAPILPE GKQAIARIGEFLRKQIG Description Functional site 1) chain A residue 77 type sequence G description binding site for residue PMS A 301 source : AC1 2) chain A residue 78 type sequence G description binding site for residue PMS A 301 source : AC1 3) chain A residue 145 type sequence S description binding site for residue PMS A 301 source : AC1 4) chain A residue 146 type sequence A description binding site for residue PMS A 301 source : AC1 5) chain A residue 175 type sequence W description binding site for residue PMS A 301 source : AC1 6) chain A residue 203 type sequence I description binding site for residue PMS A 301 source : AC1 7) chain A residue 269 type sequence H description binding site for residue PMS A 301 source : AC1 8) chain C residue 77 type sequence G description binding site for residue PMS C 301 source : AC2 9) chain C residue 78 type sequence G description binding site for residue PMS C 301 source : AC2 10) chain C residue 145 type sequence S description binding site for residue PMS C 301 source : AC2 11) chain C residue 146 type sequence A description binding site for residue PMS C 301 source : AC2 12) chain C residue 269 type sequence H description binding site for residue PMS C 301 source : AC2 13) chain D residue 77 type sequence G description binding site for residue PMS D 301 source : AC3 14) chain D residue 78 type sequence G description binding site for residue PMS D 301 source : AC3 15) chain D residue 145 type sequence S description binding site for residue PMS D 301 source : AC3 16) chain D residue 146 type sequence A description binding site for residue PMS D 301 source : AC3 17) chain D residue 175 type sequence W description binding site for residue PMS D 301 source : AC3 18) chain D residue 269 type sequence H description binding site for residue PMS D 301 source : AC3 19) chain E residue 17 type sequence R description binding site for residue PMS E 301 source : AC4 20) chain E residue 77 type sequence G description binding site for residue PMS E 301 source : AC4 21) chain E residue 78 type sequence G description binding site for residue PMS E 301 source : AC4 22) chain E residue 145 type sequence S description binding site for residue PMS E 301 source : AC4 23) chain E residue 146 type sequence A description binding site for residue PMS E 301 source : AC4 24) chain E residue 269 type sequence H description binding site for residue PMS E 301 source : AC4 25) chain F residue 76 type sequence G description binding site for residue PMS F 301 source : AC5 26) chain F residue 77 type sequence G description binding site for residue PMS F 301 source : AC5 27) chain F residue 78 type sequence G description binding site for residue PMS F 301 source : AC5 28) chain F residue 145 type sequence S description binding site for residue PMS F 301 source : AC5 29) chain F residue 146 type sequence A description binding site for residue PMS F 301 source : AC5 30) chain F residue 200 type sequence V description binding site for residue PMS F 301 source : AC5 31) chain F residue 269 type sequence H description binding site for residue PMS F 301 source : AC5 32) chain G residue 77 type sequence G description binding site for residue PMS G 301 source : AC6 33) chain G residue 78 type sequence G description binding site for residue PMS G 301 source : AC6 34) chain G residue 145 type sequence S description binding site for residue PMS G 301 source : AC6 35) chain G residue 146 type sequence A description binding site for residue PMS G 301 source : AC6 36) chain G residue 175 type sequence W description binding site for residue PMS G 301 source : AC6 37) chain G residue 203 type sequence I description binding site for residue PMS G 301 source : AC6 38) chain G residue 269 type sequence H description binding site for residue PMS G 301 source : AC6 39) chain H residue 77 type sequence G description binding site for residue PMS H 301 source : AC7 40) chain H residue 78 type sequence G description binding site for residue PMS H 301 source : AC7 41) chain H residue 145 type sequence S description binding site for residue PMS H 301 source : AC7 42) chain H residue 146 type sequence A description binding site for residue PMS H 301 source : AC7 43) chain H residue 175 type sequence W description binding site for residue PMS H 301 source : AC7 44) chain H residue 203 type sequence I description binding site for residue PMS H 301 source : AC7 45) chain H residue 269 type sequence H description binding site for residue PMS H 301 source : AC7 46) chain B residue 76 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 47) chain B residue 77 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 48) chain B residue 78 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 49) chain B residue 144 type sequence D description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 50) chain B residue 146 type sequence A description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 51) chain B residue 147 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 52) chain B residue 148 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 53) chain B residue 149 type sequence G description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 54) chain B residue 172 type sequence L description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 55) chain B residue 173 type sequence S description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 56) chain B residue 174 type sequence P description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 57) chain B residue 175 type sequence W description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 58) chain B residue 203 type sequence I description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 59) chain B residue 269 type sequence H description binding site for Di-peptide PMS B 301 and SER B 145 source : AC8 60) chain A residue 71-87 type prosite sequence FLYLHGGGYVIGSMRTH description LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. FLyLHGGGYvigSmrTH source prosite : PS01173

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