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eF-site ID
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4xv3-B |
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PDB Code
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4xv3 |
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Chain
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B |
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click to enlarge
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Title
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B-Raf Kinase V600E oncogenic mutant in complex with PLX7922 |
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Classification
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TRANSFERASE/TRANSFERASE INHIBITOR |
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Compound
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Serine/threonine-protein kinase B-raf |
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Source
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Homo sapiens (Human) (BRAF_HUMAN) |
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Sequence
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B: |
DDWEIPDGQITVGQRIGVYKGKWHGDVAVKMLNVTAPTPQ
QLQAFKNEVGVLRKTRHVNILLFMGYSTLAIVTQWCEGSS
LYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD
LKSNNIFLHTVKIGDFATEGSILWMAPEVINPYSFQSDVY
AFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSK
VRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELA
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Description
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Functional site
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|
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1)
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chain |
B |
| residue |
671 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
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| source |
Swiss-Prot : SWS_FT_FI5
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|
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2)
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chain |
B |
| residue |
578 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
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| source |
Swiss-Prot : SWS_FT_FI6
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|
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3)
|
chain |
B |
| residue |
576 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
B |
| residue |
463 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
B |
| residue |
483 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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