eF-site ID 4xum-AB PDB Code 4xum Chain A, B click to enlarge Title PPARgamma ligand binding domain in complex with indomethacin Classification TRANSLATION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKKEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMSLHPLLQEIYKDLY B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGSPFVIYD MNSLMMGEDKIKFKHITPEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMSLHPLLQEIYKDLY Description Functional site 1) chain A residue 282 type sequence F description binding site for residue IMN A 501 source : AC1 2) chain A residue 285 type sequence C description binding site for residue IMN A 501 source : AC1 3) chain A residue 289 type sequence S description binding site for residue IMN A 501 source : AC1 4) chain A residue 323 type sequence H description binding site for residue IMN A 501 source : AC1 5) chain A residue 327 type sequence Y description binding site for residue IMN A 501 source : AC1 6) chain A residue 356 type sequence L description binding site for residue IMN A 501 source : AC1 7) chain A residue 360 type sequence F description binding site for residue IMN A 501 source : AC1 8) chain A residue 363 type sequence F description binding site for residue IMN A 501 source : AC1 9) chain A residue 364 type sequence M description binding site for residue IMN A 501 source : AC1 10) chain A residue 449 type sequence H description binding site for residue IMN A 501 source : AC1 11) chain A residue 465 type sequence L description binding site for residue IMN A 501 source : AC1 12) chain A residue 469 type sequence L description binding site for residue IMN A 501 source : AC1 13) chain A residue 473 type sequence Y description binding site for residue IMN A 501 source : AC1 14) chain A residue 259 type sequence E description binding site for residue IMN A 502 source : AC2 15) chain A residue 280 type sequence R description binding site for residue IMN A 502 source : AC2 16) chain A residue 281 type sequence I description binding site for residue IMN A 502 source : AC2 17) chain A residue 285 type sequence C description binding site for residue IMN A 502 source : AC2 18) chain A residue 288 type sequence R description binding site for residue IMN A 502 source : AC2 19) chain A residue 341 type sequence I description binding site for residue IMN A 502 source : AC2 20) chain A residue 342 type sequence S description binding site for residue IMN A 502 source : AC2 21) chain A residue 348 type sequence M description binding site for residue IMN A 502 source : AC2 22) chain B residue 284 type sequence G description binding site for residue IMN B 501 source : AC3 23) chain B residue 285 type sequence C description binding site for residue IMN B 501 source : AC3 24) chain B residue 288 type sequence R description binding site for residue IMN B 501 source : AC3 25) chain B residue 289 type sequence S description binding site for residue IMN B 501 source : AC3 26) chain B residue 326 type sequence I description binding site for residue IMN B 501 source : AC3 27) chain B residue 330 type sequence L description binding site for residue IMN B 501 source : AC3 28) chain B residue 333 type sequence L description binding site for residue IMN B 501 source : AC3 29) chain B residue 340 type sequence L description binding site for residue IMN B 501 source : AC3 30) chain B residue 341 type sequence I description binding site for residue IMN B 501 source : AC3 31) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 35) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 36) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 37) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 38) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 39) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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