eF-site ID 4xsz-D PDB Code 4xsz Chain D click to enlarge Title Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme Classification transcription/antibiotic Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Escherichia coli O139:H28 (strain E24377A / ETEC); Sequence D:  LKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYR TFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEK CGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLL LDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLD ALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNE TNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPP DLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAA PDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSL ADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCG LPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAV VWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAI QLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMST NNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVL TGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKT SLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNT CYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIP EKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWA AANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMAD SGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGL NVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDL VVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAED VLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVS CDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPG TQLTTGGLPRVADLFEARRPKEPAILAEISGIVSFGKETK GKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVI SDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKIND KHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANR ELEANGKVGATYSRDLLGITKASLATESFISAASFQETTR VLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRM RRRAAG Description Functional site 1) chain D residue 749 type sequence K description binding site for residue 42U C 1401 source : AC1 2) chain D residue 750 type sequence P description binding site for residue 42U C 1401 source : AC1 3) chain D residue 755 type sequence I description binding site for residue 42U C 1401 source : AC1 4) chain D residue 773 type sequence F description binding site for residue 42U C 1401 source : AC1 5) chain D residue 774 type sequence I description binding site for residue 42U C 1401 source : AC1 6) chain D residue 777 type sequence H description binding site for residue 42U C 1401 source : AC1 7) chain D residue 460 type sequence D description binding site for residue MG D 1501 source : AC2 8) chain D residue 462 type sequence D description binding site for residue MG D 1501 source : AC2 9) chain D residue 464 type sequence D description binding site for residue MG D 1501 source : AC2 10) chain D residue 70 type sequence C description binding site for residue ZN D 1502 source : AC3 11) chain D residue 72 type sequence C description binding site for residue ZN D 1502 source : AC3 12) chain D residue 85 type sequence C description binding site for residue ZN D 1502 source : AC3 13) chain D residue 88 type sequence C description binding site for residue ZN D 1502 source : AC3 14) chain D residue 814 type sequence C description binding site for residue ZN D 1503 source : AC4 15) chain D residue 888 type sequence C description binding site for residue ZN D 1503 source : AC4 16) chain D residue 895 type sequence C description binding site for residue ZN D 1503 source : AC4 17) chain D residue 898 type sequence C description binding site for residue ZN D 1503 source : AC4 18) chain D residue 895 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 898 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 85 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 88 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 460 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 462 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 464 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 814 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 888 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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