eF-site ID 4xsz-D
PDB Code 4xsz
Chain D

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Title Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme
Classification transcription/antibiotic
Compound DNA-directed RNA polymerase subunit alpha
Source ORGANISM_SCIENTIFIC: Escherichia coli O139:H28 (strain E24377A / ETEC);
Sequence D:  LKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYR
TFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEK
CGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLL
LDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLD
ALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNE
TNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPP
DLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAA
PDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSL
ADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCG
LPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAV
VWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAI
QLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMST
NNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVL
TGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKT
SLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNT
CYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIP
EKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWA
AANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMAD
SGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGL
NVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDL
VVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAED
VLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVS
CDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPG
TQLTTGGLPRVADLFEARRPKEPAILAEISGIVSFGKETK
GKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVI
SDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKIND
KHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANR
ELEANGKVGATYSRDLLGITKASLATESFISAASFQETTR
VLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRM
RRRAAG
Description


Functional site

1) chain D
residue 749
type
sequence K
description binding site for residue 42U C 1401
source : AC1

2) chain D
residue 750
type
sequence P
description binding site for residue 42U C 1401
source : AC1

3) chain D
residue 755
type
sequence I
description binding site for residue 42U C 1401
source : AC1

4) chain D
residue 773
type
sequence F
description binding site for residue 42U C 1401
source : AC1

5) chain D
residue 774
type
sequence I
description binding site for residue 42U C 1401
source : AC1

6) chain D
residue 777
type
sequence H
description binding site for residue 42U C 1401
source : AC1

7) chain D
residue 460
type
sequence D
description binding site for residue MG D 1501
source : AC2

8) chain D
residue 462
type
sequence D
description binding site for residue MG D 1501
source : AC2

9) chain D
residue 464
type
sequence D
description binding site for residue MG D 1501
source : AC2

10) chain D
residue 70
type
sequence C
description binding site for residue ZN D 1502
source : AC3

11) chain D
residue 72
type
sequence C
description binding site for residue ZN D 1502
source : AC3

12) chain D
residue 85
type
sequence C
description binding site for residue ZN D 1502
source : AC3

13) chain D
residue 88
type
sequence C
description binding site for residue ZN D 1502
source : AC3

14) chain D
residue 814
type
sequence C
description binding site for residue ZN D 1503
source : AC4

15) chain D
residue 888
type
sequence C
description binding site for residue ZN D 1503
source : AC4

16) chain D
residue 895
type
sequence C
description binding site for residue ZN D 1503
source : AC4

17) chain D
residue 898
type
sequence C
description binding site for residue ZN D 1503
source : AC4

18) chain D
residue 895
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

19) chain D
residue 898
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

20) chain D
residue 85
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

21) chain D
residue 88
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

22) chain D
residue 460
type DNA_BIND
sequence D
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

23) chain D
residue 462
type DNA_BIND
sequence D
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

24) chain D
residue 464
type DNA_BIND
sequence D
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

25) chain D
residue 814
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1

26) chain D
residue 888
type DNA_BIND
sequence C
description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
source Swiss-Prot : SWS_FT_FI1


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