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eF-site ID
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4xsy-F |
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PDB Code
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4xsy |
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Chain
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F |
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click to enlarge
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Title
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Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme |
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Classification
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transcription/antibiotic |
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Compound
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DNA-directed RNA polymerase subunit alpha |
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Source
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ORGANISM_SCIENTIFIC: Escherichia coli O139:H28 (strain E24377A / ETEC); |
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Sequence
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F: |
GRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQ
CSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDDPEL
AREKFAELRAQYVVTRDTIKATAQEEILKLSEVFKQFRLV
PKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNF
ITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQ
KLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEA
NLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYR
RGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINK
LNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAK
EPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRA
ATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDV
TRERIRQIEAKALRKLRHPSRSEVLRSFLD
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Description
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Functional site
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1)
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chain |
F |
| residue |
573-592 |
| type |
DNA_BIND |
| sequence |
LEEVGKQFDVTRERIRQIEA
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| description |
H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
F |
| residue |
403-416 |
| type |
prosite |
| sequence |
DLIQEGNIGLMKAV
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| description |
SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV
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| source |
prosite : PS00715
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3)
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chain |
F |
| residue |
572-598 |
| type |
prosite |
| sequence |
TLEEVGKQFDVTRERIRQIEAKALRKL
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| description |
SIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL
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| source |
prosite : PS00716
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4)
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chain |
F |
| residue |
562 |
| type |
SITE |
| sequence |
R
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| description |
Interaction with anti-sigma factors
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| source |
Swiss-Prot : SWS_FT_FI2
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