eF-site ID 4xsx-I
PDB Code 4xsx
Chain I

click to enlarge
Title Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme
Classification transcription/antibiotic
Compound DNA-directed RNA polymerase subunit alpha
Source ORGANISM_SCIENTIFIC: Escherichia coli O139:H28 (strain E24377A / ETEC);
Sequence I:  YSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQD
PEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDV
QECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEV
YMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKG
KTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRR
KLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELV
PERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDV
KLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLL
AKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSA
LVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGR
MKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEV
DDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLG
DLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLS
EITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIE
TPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDE
IHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGES
SLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMG
ANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGG
VVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQN
TCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRV
AFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRD
TKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDI
LVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPN
GVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSE
ELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGL
TDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDL
APGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPI
EDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAK
GIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLS
TFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLG
DLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDK
MHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYG
AAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPES
FNVLLKEIRSLGINIELEDE
Description


Functional site

1) chain I
residue 550
type
sequence V
description binding site for residue 42S I 1401
source : AC5

2) chain I
residue 552
type
sequence P
description binding site for residue 42S I 1401
source : AC5

3) chain I
residue 555
type
sequence Y
description binding site for residue 42S I 1401
source : AC5

4) chain I
residue 640
type
sequence G
description binding site for residue 42S I 1401
source : AC5

5) chain I
residue 642
type
sequence S
description binding site for residue 42S I 1401
source : AC5


Display surface

Download
Links