eF-site ID 4xq8-AB PDB Code 4xq8 Chain A, B click to enlarge Title Human DNA polymerase lambda- MgdATP binary complex and complex with 6 paired DNA Classification TRANSFERASE/DNA Compound DNA polymerase lambda Source Homo sapiens (Human) (4XQ8) Sequence A:  VPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTT QQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLL CVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL RQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDI IVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHA LSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPA ERDW B:  SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR EPAERDW Description Functional site 1) chain A residue 386 type sequence R description binding site for residue DTP A 601 source : AC1 2) chain A residue 416 type sequence G description binding site for residue DTP A 601 source : AC1 3) chain A residue 417 type sequence S description binding site for residue DTP A 601 source : AC1 4) chain A residue 420 type sequence R description binding site for residue DTP A 601 source : AC1 5) chain A residue 426 type sequence G description binding site for residue DTP A 601 source : AC1 6) chain A residue 427 type sequence D description binding site for residue DTP A 601 source : AC1 7) chain A residue 429 type sequence D description binding site for residue DTP A 601 source : AC1 8) chain A residue 505 type sequence Y description binding site for residue DTP A 601 source : AC1 9) chain A residue 506 type sequence F description binding site for residue DTP A 601 source : AC1 10) chain A residue 508 type sequence G description binding site for residue DTP A 601 source : AC1 11) chain A residue 513 type sequence N description binding site for residue DTP A 601 source : AC1 12) chain A residue 427 type sequence D description binding site for residue MG A 602 source : AC2 13) chain A residue 429 type sequence D description binding site for residue MG A 602 source : AC2 14) chain B residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 15) chain B residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 16) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 17) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 18) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 19) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 20) chain B residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 21) chain B residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 22) chain B residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 23) chain B residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 24) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 25) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 26) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 27) chain B residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 28) chain B residue 416-435 type prosite sequence GSYRRGKATCGDVDVLITHP description DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP source prosite : PS00522

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