eF-site ID 4xp1-AHL
PDB Code 4xp1
Chain A, H, L

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Title X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Classification membrane protein/transport protein
Compound Dopamine transporter, isoform B
Source (4XP1)
Sequence A:  DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGA
FLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVP
LFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLP
WTSCNNIWNTPNCRPFEGHVEGFQSAASEYFNRYILELNR
SEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV
WFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIY
KAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDA
LLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEG
PGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGG
SEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ
GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSE
DIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPL
TYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGS
LRQRFTILTTPWRDQ
H:  EVQLVESGGGLVKPGGSLKLSCAASGFTFSSYAMSWVRQS
PEKRLEWVAEISSGGRYIYYSDTVTGRFTISRDNARNILH
LEMSSLRSEDTAMYYCARGEVRQRGFDYWGQGTTLTVSSA
KTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTW
NSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSIT
CNVAHPASSTKVDKKIEPR
L:  ENVLTQSPAIMSTSPGEKVTMTCRASSSVGSSYLHWYQQK
SGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSVE
AEDAATYYCQQFSGYPLTFGSGTKLEMKRADAAPTVSIFP
PSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGV
LNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHK
TSTSPIVKSFNRNE
Description (1)  dopamine transporter


Functional site
1) chain A
residue 34-59
type TRANSMEM
sequence VDFLLSVIGFAVDLANVWRFPYLCYK
description Helical; Name=1 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI1
2) chain A
residue 446-471
type TRANSMEM
sequence LFVAGLFSLYFVVGLASCTQGGFYFF
description Helical; Name=8 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI10
3) chain A
residue 487-507
type TRANSMEM
sequence VFFEAIAVSWIYGTNRFSEDI
description Helical; Name=9 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI11
4) chain A
residue 42
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
5) chain A
residue 44
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
6) chain A
residue 45
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
7) chain A
residue 49
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
8) chain A
residue 361
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
9) chain A
residue 393
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
10) chain A
residue 458
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
11) chain A
residue 461
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
12) chain A
residue 462
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI15
13) chain A
residue 46
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI16
14) chain A
residue 117
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI16
15) chain A
residue 121
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI16
16) chain A
residue 509-535
type TRANSMEM
sequence DMIGFPPGRYWQVCWRFVAPIFLLFIT
description Helical; Name=10 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI12
17) chain A
residue 566-588
type TRANSMEM
sequence SSVVMIPAVAIFKLLSTPGSLRQ
description Helical; Name=11 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI13
18) chain A
residue 60-63
type TOPO_DOM
sequence NGGG
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
19) chain A
residue 139-276
type TOPO_DOM
sequence FTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEYFNRY
ILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGIS
TSGKVVWFTALFPYAVL
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
20) chain A
residue 326-349
type TOPO_DOM
sequence GVLLAYASYNKYHNNVYKDALLTS
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
21) chain A
residue 406-445
type TOPO_DOM
sequence WALIFFMMLATLGLDSSFGGSEAIITALSDEFPKIKRNRE
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
22) chain A
residue 508
type TOPO_DOM
sequence R
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
23) chain A
residue 589-591
type TOPO_DOM
sequence RFT
description Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI2
24) chain A
residue 64-87
type TRANSMEM
sequence AFLVPYGIMLAVGGIPLFYMELAL
description Helical; Name=2 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI3
25) chain A
residue 88-107
type TOPO_DOM
sequence GQHNRKGAITCWGRLVPLFK
description Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI4
26) chain A
residue 298-300
type TOPO_DOM
sequence TPN
description Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI4
27) chain A
residue 376-381
type TOPO_DOM
sequence VRIEDV
description Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI4
28) chain A
residue 472-486
type TOPO_DOM
sequence HLLDRYAAGYSILVA
description Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI4
29) chain A
residue 536-565
type TOPO_DOM
sequence VYGLIGYEPLTYADYVYPSWANALGWCIAG
description Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI4
30) chain A
residue 108-138
type TRANSMEM
sequence GIGYAVVLIAFYVDFYYNVIIAWSLRFFFAS
description Helical; Name=3 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI5
31) chain A
residue 277-297
type TRANSMEM
sequence LILLIRGLTLPGSFLGIQYYL
description Helical; Name=4 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI6
32) chain A
residue 301-325
type TRANSMEM
sequence FSAIYKAEVWVDAATQVFFSLGPGF
description Helical; Name=5 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI7
33) chain A
residue 350-375
type TRANSMEM
sequence FINSATSFIAGFVIFSVLGYMAHTLG
description Helical; Name=6 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI8
34) chain A
residue 382-405
type TRANSMEM
sequence ATEGPGLVFVVYPAAIATMPASTF
description Helical; Name=7 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245
source Swiss-Prot : SWS_FT_FI9
35) chain L
residue 193-199
type prosite
sequence YTCEATH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
source prosite : PS00290
36) chain A
residue 51-65
type prosite
sequence WRFPYLCYKNGGGAF
description NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF
source prosite : PS00610
37) chain A
residue 134-154
type prosite
sequence FFFASFTNSLPWTSCNNIWNT
description NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. FFfaSFTnsLPWtsCnniwNT
source prosite : PS00754
38) chain A
residue 141
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1
source Swiss-Prot : SWS_FT_FI17
39) chain A
residue 205
type CARBOHYD
sequence V
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
40) chain A
residue 214
type CARBOHYD
sequence E
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
41) chain A
residue 223
type CARBOHYD
sequence L
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
42) chain A
residue 229
type CARBOHYD
sequence I
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
43) chain A
residue 234
type CARBOHYD
sequence A
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
44) chain A
residue 265
type CARBOHYD
sequence V
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18
45) chain A
residue 341
type CARBOHYD
sequence V
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI18

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