eF-site ID 4xld-A PDB Code 4xld Chain A click to enlarge Title Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction Classification GENE REGULATION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKT SPFVIYDMNSLMMGEDKIKFKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLM NKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQ VIKKTETDMSLHPLLQEIYKDLY Description Functional site 1) chain A residue 282 type sequence F description binding site for residue BRL A 502 source : AC1 2) chain A residue 285 type sequence C description binding site for residue BRL A 502 source : AC1 3) chain A residue 289 type sequence S description binding site for residue BRL A 502 source : AC1 4) chain A residue 323 type sequence H description binding site for residue BRL A 502 source : AC1 5) chain A residue 327 type sequence Y description binding site for residue BRL A 502 source : AC1 6) chain A residue 341 type sequence I description binding site for residue BRL A 502 source : AC1 7) chain A residue 363 type sequence F description binding site for residue BRL A 502 source : AC1 8) chain A residue 364 type sequence M description binding site for residue BRL A 502 source : AC1 9) chain A residue 449 type sequence H description binding site for residue BRL A 502 source : AC1 10) chain A residue 473 type sequence Y description binding site for residue BRL A 502 source : AC1 11) chain A residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 12) chain A residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 13) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 14) chain A residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links