eF-site ID 4xfs-AB PDB Code 4xfs Chain A, B click to enlarge Title Structure of IL-18 SER Mutant I Classification CYTOKINE Compound Interleukin-18 Source (IL18_HUMAN) Sequence A:  YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRD NAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKI ISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSY EGYFLACEKERDLFKLILAAADAAGDRSIMFTVQNE B:  YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRD NAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKI ISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSY EGYFLACEKERDLFKLILAAADAAGDRSIMFTVQNED Description Functional site 1) chain A residue 114 type sequence Q description binding site for residue DMS A 201 source : AC1 2) chain A residue 124 type sequence F description binding site for residue DMS A 201 source : AC1 3) chain A residue 142 type sequence D description binding site for residue DMS A 201 source : AC1 4) chain A residue 143 type sequence A description binding site for residue DMS A 201 source : AC1 5) chain A residue 144 type sequence A description binding site for residue DMS A 201 source : AC1 6) chain A residue 149 type sequence I description binding site for residue DMS A 201 source : AC1 7) chain A residue 155 type sequence N description binding site for residue DMS A 202 source : AC2 8) chain B residue 109 type sequence H description binding site for residue DMS A 202 source : AC2 9) chain A residue 7 type sequence S description binding site for residue DMS A 203 source : AC3 10) chain A residue 8 type sequence K description binding site for residue DMS A 203 source : AC3 11) chain A residue 9 type sequence L description binding site for residue DMS A 203 source : AC3 12) chain A residue 144 type sequence A description binding site for residue DMS A 203 source : AC3 13) chain A residue 145 type sequence G description binding site for residue DMS A 203 source : AC3 14) chain A residue 156 type sequence E description binding site for residue DMS A 203 source : AC3 15) chain A residue 58 type sequence R description binding site for residue GOL A 204 source : AC4 16) chain A residue 59 type sequence G description binding site for residue GOL A 204 source : AC4 17) chain A residue 104 type sequence R description binding site for residue GOL A 204 source : AC4 18) chain B residue 58 type sequence R description binding site for residue GOL A 204 source : AC4 19) chain B residue 59 type sequence G description binding site for residue GOL A 204 source : AC4 20) chain B residue 104 type sequence R description binding site for residue GOL A 204 source : AC4 21) chain B residue 114 type sequence Q description binding site for residue DMS B 201 source : AC5 22) chain B residue 142 type sequence D description binding site for residue DMS B 201 source : AC5 23) chain B residue 143 type sequence A description binding site for residue DMS B 201 source : AC5 24) chain B residue 144 type sequence A description binding site for residue DMS B 201 source : AC5 25) chain B residue 149 type sequence I description binding site for residue DMS B 201 source : AC5 26) chain B residue 146 type sequence D description binding site for residue DMS B 202 source : AC6 27) chain B residue 70 type sequence K description binding site for residue GOL B 203 source : AC7 28) chain B residue 71 type sequence I description binding site for residue GOL B 203 source : AC7 29) chain B residue 87 type sequence N description binding site for residue GOL B 203 source : AC7 30) chain B residue 140 type sequence A description binding site for residue GOL B 203 source : AC7 31) chain A residue 35 type SITE sequence D description Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 35 type SITE sequence D description Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240 source Swiss-Prot : SWS_FT_FI1

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