eF-site ID 4xem-A PDB Code 4xem Chain A click to enlarge Title Crystal Structure of wild type human AlaRS catalytic domain Classification LIGASE Compound Alanine--tRNA ligase, cytoplasmic Source Homo sapiens (Human) (SYAC_HUMAN) Sequence A:  TLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFAN AGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGDLDD VGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFG IPIERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKIL PGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQD DPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERL VSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAED ADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRI LRRAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKD PDMVKDIINEEEVQFLK Description Functional site 1) chain A residue 44 type sequence A description binding site for residue A5A A 501 source : AC1 2) chain A residue 77 type sequence R description binding site for residue A5A A 501 source : AC1 3) chain A residue 93 type sequence Y description binding site for residue A5A A 501 source : AC1 4) chain A residue 94 type sequence H description binding site for residue A5A A 501 source : AC1 5) chain A residue 95 type sequence H description binding site for residue A5A A 501 source : AC1 6) chain A residue 98 type sequence F description binding site for residue A5A A 501 source : AC1 7) chain A residue 100 type sequence M description binding site for residue A5A A 501 source : AC1 8) chain A residue 176 type sequence W description binding site for residue A5A A 501 source : AC1 9) chain A residue 189 type sequence E description binding site for residue A5A A 501 source : AC1 10) chain A residue 213 type sequence E description binding site for residue A5A A 501 source : AC1 11) chain A residue 214 type sequence I description binding site for residue A5A A 501 source : AC1 12) chain A residue 216 type sequence N description binding site for residue A5A A 501 source : AC1 13) chain A residue 218 type sequence V description binding site for residue A5A A 501 source : AC1 14) chain A residue 239 type sequence D description binding site for residue A5A A 501 source : AC1 15) chain A residue 240 type sequence T description binding site for residue A5A A 501 source : AC1 16) chain A residue 241 type sequence G description binding site for residue A5A A 501 source : AC1 17) chain A residue 243 type sequence G description binding site for residue A5A A 501 source : AC1 18) chain A residue 246 type sequence R description binding site for residue A5A A 501 source : AC1 19) chain A residue 336 type sequence H description binding site for residue EDO A 502 source : AC2 20) chain A residue 341 type sequence A description binding site for residue EDO A 502 source : AC2 21) chain A residue 342 type sequence S description binding site for residue EDO A 502 source : AC2 22) chain A residue 343 type sequence R description binding site for residue EDO A 502 source : AC2 23) chain A residue 383 type sequence L description binding site for residue EDO A 502 source : AC2 24) chain A residue 189 type sequence E description binding site for residue EDO A 503 source : AC3 25) chain A residue 171 type sequence M description binding site for residue EDO A 504 source : AC4 26) chain A residue 224 type sequence R description binding site for residue EDO A 504 source : AC4 27) chain A residue 317 type sequence N description binding site for residue EDO A 504 source : AC4 28) chain A residue 322 type sequence Y description binding site for residue EDO A 504 source : AC4 29) chain A residue 267 type sequence F description binding site for residue EDO A 505 source : AC5 30) chain A residue 278 type sequence P description binding site for residue EDO A 505 source : AC5 31) chain A residue 279 type sequence Y description binding site for residue EDO A 505 source : AC5 32) chain A residue 295 type sequence Y description binding site for residue EDO A 505 source : AC5 33) chain A residue 12 type sequence Q description binding site for residue EDO A 506 source : AC6 34) chain A residue 25 type sequence Y description binding site for residue EDO A 506 source : AC6 35) chain A residue 277 type sequence R description binding site for residue EDO A 506 source : AC6 36) chain A residue 95 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 37) chain A residue 176 type BINDING sequence W description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 38) chain A residue 214 type BINDING sequence I description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 39) chain A residue 216 type BINDING sequence N description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 40) chain A residue 239 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 41) chain A residue 243 type BINDING sequence G description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 42) chain A residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN source Swiss-Prot : SWS_FT_FI1 43) chain A residue 8 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 44) chain A residue 19 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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