eF-site ID 4xbj-ABCD PDB Code 4xbj Chain A, B, C, D click to enlarge Title Y274F alanine racemase from E. coli inhibited by l-ala-p Classification ISOMERASE/ISOMERASE INHIBITOR Compound Alanine racemase, biosynthetic Source null (ALR1_ECOLI) Sequence A:  AATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGL LETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFF DARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMK LDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFAR ADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQ SHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLI AVREHKAGEPVGYGGTWVSERDTRLGVVAMGFGDGYPRAA PSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPV ILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD B:  QAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHG LLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGF FDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWM KLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFA RADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWP QSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSL IAVREHKAGEPVGYGGTWVSERDTRLGVVAMGFGDGYPRA APSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDP VILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD C:  AATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGL LETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFF DARDLPTISAQHFHTAVHNEEQLAALEEALDEPVTVWMKL DTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARA DEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQS HFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIA VREHKAGEPVGYGGTWVSRDTRLGVVAMGFGDGYPRAAPS GTPVLVNREVPIVGRVAMDMICVDLGPQAQDKAGDPVILW GGLPVERIMTKVSAYELITRLTSRVAMKYVD D:  ATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLL ETARTLPADAFGVARLEEALRLRAGGITKPVLLLEGFFDA RDLPTISAQHFHTAVHNEEQLAALEEASDEPVTVWMKLDT GMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADE PCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFD WVRPGIILYGVSPLRSTGADFGCQPVMSLTSSLIAVREHK AGEPVGYGGTWVSERDTRLGVVAMGFGDGYPRAAPSGTPV LVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEG LPVERIAEMTKVSAYELITRLTSRVAMKYVD Description Functional site 1) chain A residue 34 type sequence K description binding site for residue IN5 A 401 source : AC1 2) chain A residue 38 type sequence Y description binding site for residue IN5 A 401 source : AC1 3) chain A residue 129 type sequence R description binding site for residue IN5 A 401 source : AC1 4) chain A residue 159 type sequence H description binding site for residue IN5 A 401 source : AC1 5) chain A residue 193 type sequence A description binding site for residue IN5 A 401 source : AC1 6) chain A residue 194 type sequence S description binding site for residue IN5 A 401 source : AC1 7) chain A residue 209 type sequence R description binding site for residue IN5 A 401 source : AC1 8) chain A residue 211 type sequence G description binding site for residue IN5 A 401 source : AC1 9) chain A residue 212 type sequence I description binding site for residue IN5 A 401 source : AC1 10) chain A residue 343 type sequence Y description binding site for residue IN5 A 401 source : AC1 11) chain B residue 255 type sequence Y description binding site for residue IN5 A 401 source : AC1 12) chain B residue 302 type sequence A description binding site for residue IN5 A 401 source : AC1 13) chain B residue 303 type sequence M description binding site for residue IN5 A 401 source : AC1 14) chain B residue 304 type sequence D description binding site for residue IN5 A 401 source : AC1 15) chain A residue 122 type sequence K description binding site for residue SO4 A 402 source : AC2 16) chain A residue 129 type sequence R description binding site for residue SO4 A 402 source : AC2 17) chain A residue 130 type sequence L description binding site for residue SO4 A 402 source : AC2 18) chain A residue 159 type sequence H description binding site for residue SO4 A 402 source : AC2 19) chain A residue 266 type sequence R description binding site for residue SO4 A 403 source : AC3 20) chain B residue 19 type sequence R description binding site for residue SO4 A 403 source : AC3 21) chain A residue 19 type sequence R description binding site for residue SO4 A 404 source : AC4 22) chain B residue 266 type sequence R description binding site for residue SO4 A 404 source : AC4 23) chain A residue 255 type sequence Y description binding site for residue IN5 B 401 source : AC5 24) chain A residue 302 type sequence A description binding site for residue IN5 B 401 source : AC5 25) chain A residue 303 type sequence M description binding site for residue IN5 B 401 source : AC5 26) chain B residue 34 type sequence K description binding site for residue IN5 B 401 source : AC5 27) chain B residue 38 type sequence Y description binding site for residue IN5 B 401 source : AC5 28) chain B residue 129 type sequence R description binding site for residue IN5 B 401 source : AC5 29) chain B residue 159 type sequence H description binding site for residue IN5 B 401 source : AC5 30) chain B residue 193 type sequence A description binding site for residue IN5 B 401 source : AC5 31) chain B residue 194 type sequence S description binding site for residue IN5 B 401 source : AC5 32) chain B residue 209 type sequence R description binding site for residue IN5 B 401 source : AC5 33) chain B residue 211 type sequence G description binding site for residue IN5 B 401 source : AC5 34) chain B residue 212 type sequence I description binding site for residue IN5 B 401 source : AC5 35) chain B residue 343 type sequence Y description binding site for residue IN5 B 401 source : AC5 36) chain B residue 122 type sequence K description binding site for residue SO4 B 402 source : AC6 37) chain B residue 127 type sequence M description binding site for residue SO4 B 402 source : AC6 38) chain B residue 129 type sequence R description binding site for residue SO4 B 402 source : AC6 39) chain B residue 130 type sequence L description binding site for residue SO4 B 402 source : AC6 40) chain B residue 159 type sequence H description binding site for residue SO4 B 402 source : AC6 41) chain C residue 34 type sequence K description binding site for residue IN5 C 401 source : AC7 42) chain C residue 38 type sequence Y description binding site for residue IN5 C 401 source : AC7 43) chain C residue 129 type sequence R description binding site for residue IN5 C 401 source : AC7 44) chain C residue 159 type sequence H description binding site for residue IN5 C 401 source : AC7 45) chain C residue 193 type sequence A description binding site for residue IN5 C 401 source : AC7 46) chain C residue 194 type sequence S description binding site for residue IN5 C 401 source : AC7 47) chain C residue 209 type sequence R description binding site for residue IN5 C 401 source : AC7 48) chain C residue 211 type sequence G description binding site for residue IN5 C 401 source : AC7 49) chain C residue 212 type sequence I description binding site for residue IN5 C 401 source : AC7 50) chain C residue 343 type sequence Y description binding site for residue IN5 C 401 source : AC7 51) chain D residue 255 type sequence Y description binding site for residue IN5 C 401 source : AC7 52) chain D residue 302 type sequence A description binding site for residue IN5 C 401 source : AC7 53) chain D residue 303 type sequence M description binding site for residue IN5 C 401 source : AC7 54) chain D residue 304 type sequence D description binding site for residue IN5 C 401 source : AC7 55) chain C residue 246 type sequence E description binding site for residue SO4 C 402 source : AC8 56) chain C residue 266 type sequence R description binding site for residue SO4 C 402 source : AC8 57) chain C residue 122 type sequence K description binding site for residue SO4 C 403 source : AC9 58) chain C residue 127 type sequence M description binding site for residue SO4 C 403 source : AC9 59) chain C residue 129 type sequence R description binding site for residue SO4 C 403 source : AC9 60) chain C residue 130 type sequence L description binding site for residue SO4 C 403 source : AC9 61) chain C residue 159 type sequence H description binding site for residue SO4 C 403 source : AC9 62) chain C residue 19 type sequence R description binding site for residue SO4 C 404 source : AD1 63) chain D residue 266 type sequence R description binding site for residue SO4 C 404 source : AD1 64) chain D residue 317 type sequence K description binding site for residue SO4 C 404 source : AD1 65) chain D residue 38 type sequence Y description binding site for residue SO4 D 401 source : AD2 66) chain D residue 193 type sequence A description binding site for residue SO4 D 401 source : AD2 67) chain D residue 194 type sequence S description binding site for residue SO4 D 401 source : AD2 68) chain D residue 211 type sequence G description binding site for residue SO4 D 401 source : AD2 69) chain D residue 212 type sequence I description binding site for residue SO4 D 401 source : AD2 70) chain D residue 343 type sequence Y description binding site for residue SO4 D 401 source : AD2 71) chain A residue 31-41 type prosite sequence AVVKANAYGHG description ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGHG source prosite : PS00395 72) chain B residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 73) chain C residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 74) chain D residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 75) chain A residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 77) chain C residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 78) chain D residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 79) chain A residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 80) chain C residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 81) chain C residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 82) chain D residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 83) chain D residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 84) chain B residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 85) chain B residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 86) chain A residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 87) chain A residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 88) chain B residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 89) chain C residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 90) chain D residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 91) chain A residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 92) chain B residue 122 type MOD_RES sequence K description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 93) chain C residue 122 type MOD_RES sequence K description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 94) chain D residue 122 type MOD_RES sequence K description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 95) chain A residue 122 type MOD_RES sequence K description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5

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