eF-site ID 4xbj-A PDB Code 4xbj Chain A click to enlarge Title Y274F alanine racemase from E. coli inhibited by l-ala-p Classification ISOMERASE/ISOMERASE INHIBITOR Compound Alanine racemase, biosynthetic Source Escherichia coli (strain K12) (ALR1_ECOLI) Sequence A:  AATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGL LETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFF DARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMK LDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFAR ADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQ SHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLI AVREHKAGEPVGYGGTWVSERDTRLGVVAMGFGDGYPRAA PSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPV ILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD Description Functional site 1) chain A residue 34 type sequence K description binding site for residue IN5 A 401 source : AC1 2) chain A residue 38 type sequence Y description binding site for residue IN5 A 401 source : AC1 3) chain A residue 129 type sequence R description binding site for residue IN5 A 401 source : AC1 4) chain A residue 159 type sequence H description binding site for residue IN5 A 401 source : AC1 5) chain A residue 193 type sequence A description binding site for residue IN5 A 401 source : AC1 6) chain A residue 194 type sequence S description binding site for residue IN5 A 401 source : AC1 7) chain A residue 209 type sequence R description binding site for residue IN5 A 401 source : AC1 8) chain A residue 211 type sequence G description binding site for residue IN5 A 401 source : AC1 9) chain A residue 212 type sequence I description binding site for residue IN5 A 401 source : AC1 10) chain A residue 343 type sequence Y description binding site for residue IN5 A 401 source : AC1 11) chain A residue 122 type sequence K description binding site for residue SO4 A 402 source : AC2 12) chain A residue 129 type sequence R description binding site for residue SO4 A 402 source : AC2 13) chain A residue 130 type sequence L description binding site for residue SO4 A 402 source : AC2 14) chain A residue 159 type sequence H description binding site for residue SO4 A 402 source : AC2 15) chain A residue 266 type sequence R description binding site for residue SO4 A 403 source : AC3 16) chain A residue 19 type sequence R description binding site for residue SO4 A 404 source : AC4 17) chain A residue 255 type sequence Y description binding site for residue IN5 B 401 source : AC5 18) chain A residue 302 type sequence A description binding site for residue IN5 B 401 source : AC5 19) chain A residue 303 type sequence M description binding site for residue IN5 B 401 source : AC5 20) chain A residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 31-41 type prosite sequence AVVKANAYGHG description ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGHG source prosite : PS00395 23) chain A residue 122 type MOD_RES sequence K description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2

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