eF-site ID 4x8t-HL PDB Code 4x8t Chain H, L click to enlarge Title FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 7-chloro-3,4-dihydroisoquinolin-1(2H)-one Classification hydrolase/hydrolase inhibitor Compound Factor VIIa (Heavy Chain) Source Homo sapiens (Human) (FA7_HUMAN) Sequence H:  IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ QSRSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPR PGVLLRAPFP L:  ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTP TVEYPCGKIPILEKR Description (1)  Factor VIIa (Heavy Chain) (E.C.3.4.21.21), Factor VIIa (Light Chain) (E.C.3.4.21.21) Functional site 1) chain H residue 189 type sequence D description binding site for residue 3Z8 H 301 source : AC1 2) chain H residue 190 type sequence S description binding site for residue 3Z8 H 301 source : AC1 3) chain H residue 192 type sequence K description binding site for residue 3Z8 H 301 source : AC1 4) chain H residue 195 type sequence S description binding site for residue 3Z8 H 301 source : AC1 5) chain H residue 213 type sequence V description binding site for residue 3Z8 H 301 source : AC1 6) chain H residue 214 type sequence S description binding site for residue 3Z8 H 301 source : AC1 7) chain H residue 215 type sequence W description binding site for residue 3Z8 H 301 source : AC1 8) chain H residue 216 type sequence G description binding site for residue 3Z8 H 301 source : AC1 9) chain H residue 219 type sequence G description binding site for residue 3Z8 H 301 source : AC1 10) chain H residue 220 type sequence C description binding site for residue 3Z8 H 301 source : AC1 11) chain H residue 226 type sequence G description binding site for residue 3Z8 H 301 source : AC1 12) chain H residue 70 type sequence E description binding site for residue CA H 302 source : AC2 13) chain H residue 72 type sequence D description binding site for residue CA H 302 source : AC2 14) chain H residue 75 type sequence E description binding site for residue CA H 302 source : AC2 15) chain H residue 80 type sequence E description binding site for residue CA H 302 source : AC2 16) chain H residue 83 type sequence R description binding site for residue SO4 H 303 source : AC3 17) chain H residue 84 type sequence R description binding site for residue SO4 H 303 source : AC3 18) chain H residue 109 type sequence H description binding site for residue SO4 H 303 source : AC3 19) chain H residue 110 type sequence Q description binding site for residue SO4 H 303 source : AC3 20) chain H residue 35 type sequence V description binding site for residue SO4 H 304 source : AC4 21) chain H residue 37 type sequence N description binding site for residue SO4 H 304 source : AC4 22) chain H residue 60 type sequence D description binding site for residue SO4 H 304 source : AC4 23) chain H residue 60 type sequence D description binding site for residue SO4 H 304 source : AC4 24) chain H residue 60 type sequence D description binding site for residue SO4 H 304 source : AC4 25) chain H residue 60 type sequence D description binding site for residue SO4 H 304 source : AC4 26) chain H residue 47 type sequence I description binding site for residue SO4 H 305 source : AC5 27) chain H residue 48 type sequence N description binding site for residue SO4 H 305 source : AC5 28) chain H residue 239 type sequence Q description binding site for residue SO4 H 305 source : AC5 29) chain L residue 115 type sequence H description binding site for residue SO4 H 305 source : AC5 30) chain L residue 116 type sequence E description binding site for residue SO4 H 305 source : AC5 31) chain H residue 61 type sequence W description binding site for residue GOL H 306 source : AC6 32) chain H residue 96 type sequence P description binding site for residue GOL H 306 source : AC6 33) chain H residue 147 type sequence R description binding site for residue GOL H 306 source : AC6 34) chain H residue 251 type sequence L description binding site for residue GOL H 306 source : AC6 35) chain H residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain H residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain H residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain H residue 175 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725 source Swiss-Prot : SWS_FT_FI3 39) chain H residue 189 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 40) chain H residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 41) chain H residue 189-200 type prosite sequence DSCKGDSGGPHA description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA source prosite : PS00135 42) chain L residue 112-127 type prosite sequence CRCHEGYSLLADGVSC description EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC source prosite : PS01186

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