|
eF-site ID
|
4x6p-B |
PDB Code
|
4x6p |
Chain
|
B |
|
click to enlarge
|
|
Title
|
FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Coagulation factor XI, light chain |
Source
|
Homo sapiens (Human) (FA11_HUMAN) |
|
Sequence
|
B: |
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWIL
TAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEII
IHDQYKMAESGYDIALLKLETTVNYTDSQRPISLPSKGDR
NVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQK
RYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
57 |
type |
ACT_SITE |
sequence |
H
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
102 |
type |
ACT_SITE |
sequence |
D
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
B |
residue |
195 |
type |
ACT_SITE |
sequence |
S
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
B |
residue |
169 |
type |
BINDING |
sequence |
K
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
113 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:1998667, ECO:0000269|PubMed:25092234
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
6)
|
chain |
B |
residue |
72 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:25092234
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|