|
|
eF-site ID
|
4x6p-AB |
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PDB Code
|
4x6p |
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Chain
|
A, B |
|
click to enlarge
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Title
|
FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide |
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Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
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Compound
|
Coagulation factor XI, light chain |
|
Source
|
Homo sapiens (Human) (FA11_HUMAN) |
|
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Sequence
|
A: |
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWIL
TAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEII
IHDQYKMAESGYDIALLKLETTVNYTDSQRPISLPSKGDR
NVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQK
RYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
|
| B: |
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWIL
TAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEII
IHDQYKMAESGYDIALLKLETTVNYTDSQRPISLPSKGDR
NVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQK
RYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
|
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Description
|
|
Functional site
|
|
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1)
|
chain |
A |
| residue |
57 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
195 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
57 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
195 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
169 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
B |
| residue |
169 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
53-58 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
|
10)
|
chain |
A |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACKGDSGGPLS
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLS
|
| source |
prosite : PS00135
|
|
|
11)
|
chain |
A |
| residue |
113 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:1998667, ECO:0000269|PubMed:25092234
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
B |
| residue |
113 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:1998667, ECO:0000269|PubMed:25092234
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
13)
|
chain |
A |
| residue |
72 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:25092234
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
14)
|
chain |
B |
| residue |
72 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:25092234
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|