eF-site ID 4x67-B PDB Code 4x67 Chain B click to enlarge Title Crystal structure of elongating yeast RNA polymerase II stalled at oxidative Cyclopurine DNA lesions. Classification TRANSCRIPTION/DNA Compound DNA-directed RNA polymerase II subunit RPB1 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence B:  DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTL QDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEAR LRNLTYSSGLFVDVKKKVFIGRLPIMLRSKNCYLSEATES DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND WQMLEMLKPCVEDGFVIQDRETALDFIGKEKRIQYAKDIL QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQD DRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV ELAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLN RYTYSSTLSHLRRTNTPIAKPRQLHNTHWGLVCPAETPEG QACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYV PHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDIN PEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKE LKVRKGHIAKLMATEYQDEYTWSSLLNEGLVEYIDAEEEE SILIAMQPEDLEPAEADVDPAKRIRVSHHATTFTHCEIHP SMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNY NVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIV AIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKK YGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRV SGEDVIIGKTTPISSKRDASTPLRSTENGIVDQVLVTTNQ DGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRRED MPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALS GNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTG KKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQP VEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAF RVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPY AAKLLFQELMAMNITPRLYTDRSRDF Description (1)  DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerases I, II, and III subunit RPABC1, iaDNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerases I, II, and III subunit RPABC4/RNA Complex Functional site 1) chain B residue 1163 type sequence C description binding site for residue ZN B 1301 source : AC3 2) chain B residue 1166 type sequence C description binding site for residue ZN B 1301 source : AC3 3) chain B residue 1182 type sequence C description binding site for residue ZN B 1301 source : AC3 4) chain B residue 1185 type sequence C description binding site for residue ZN B 1301 source : AC3 5) chain B residue 837 type catalytic sequence D description 788 source MCSA : MCSA1 6) chain B residue 977-989 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166 7) chain B residue 1185 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI2

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