|
eF-site ID
|
4x67-A |
PDB Code
|
4x67 |
Chain
|
A |
|
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Title
|
Crystal structure of elongating yeast RNA polymerase II stalled at oxidative Cyclopurine DNA lesions. |
Classification
|
TRANSCRIPTION/DNA |
Compound
|
DNA-directed RNA polymerase II subunit RPB1 |
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
|
Sequence
|
A: |
GQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMD
ETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFG
HIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELM
RQALAIKDSKKRFAAIWTLCKTKMVCETDVPSLVSRGGCG
NTQPTIRKDGLKLVGSWKLRVLSTEEILNIFKHISVKDFT
SLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQRGED
DLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNL
MGKRVDFSARTVISGDPNLELDQVGVPKSIAKTLTYPEVV
TPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRV
KVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAE
LSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSV
AIPNGIHLQRFDEGTTLLSPKDNGMLIIDGQIIFGVVEKK
TVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQAN
LLTAKHGMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDL
NNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGG
REGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTRNSL
GNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDR
KFLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSD
LTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHP
GEMVGVLAAQSIGEPATQMTLKKVTSGVPRLKEILNVAKN
MKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIAS
EIYYDPDPRSTVIPEDEEIIQLHFSQQSPWLLRLELDRAA
MNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCR
VVAEEDHMLKKIENTMLENITLRGVENIERVVMMKYDRKV
PSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNS
FIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALL
VDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEILFE
AGASAELDDCRGVSENVILGQMAPIGTGAFDVMI
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Description
|
(1) |
DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerases I, II, and III subunit RPABC1, iaDNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerases I, II, and III subunit RPABC4/RNA Complex
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
107 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
108 |
type |
|
sequence |
M
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
110 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
148 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
166 |
type |
|
sequence |
G
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
6)
|
chain |
A |
residue |
167 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1801
|
source |
: AC1
|
|
7)
|
chain |
A |
residue |
67 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1802
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
68 |
type |
|
sequence |
Q
|
description |
binding site for residue ZN A 1802
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
70 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1802
|
source |
: AC2
|
|
10)
|
chain |
A |
residue |
77 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 1802
|
source |
: AC2
|
|
11)
|
chain |
A |
residue |
80 |
type |
|
sequence |
H
|
description |
binding site for residue ZN A 1802
|
source |
: AC2
|
|
12)
|
chain |
A |
residue |
483 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
13)
|
chain |
A |
residue |
485 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
14)
|
chain |
A |
residue |
483 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
15)
|
chain |
A |
residue |
485 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
16)
|
chain |
A |
residue |
107 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
17)
|
chain |
A |
residue |
110 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
18)
|
chain |
A |
residue |
148 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
19)
|
chain |
A |
residue |
167 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
20)
|
chain |
A |
residue |
481 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|