eF-site ID 4x3g-ABCD
PDB Code 4x3g
Chain A, B, C, D

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Title Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
Classification LIGASE
Compound E3 ubiquitin-protein ligase SIAH1
Source Homo sapiens (Human) (UBP19_HUMAN)
Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC
PASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDIN
LPGAVDWVMMQSCFGFHFMLVLEKQEKYQQFFAIVQLIGT
RKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNS
DCLVFDTSIAQLFAENGNLGINVTISMC
B:  SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINL
PGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
C:  PKPTCMVPPMP
D:  KPTCMVPPMP
Description


Functional site
1) chain A
residue 128
type
sequence C
description binding site for residue ZN A 601
source : AC1
2) chain A
residue 135
type
sequence C
description binding site for residue ZN A 601
source : AC1
3) chain A
residue 147
type
sequence H
description binding site for residue ZN A 601
source : AC1
4) chain A
residue 152
type
sequence H
description binding site for residue ZN A 601
source : AC1
5) chain A
residue 98
type
sequence C
description binding site for residue ZN A 602
source : AC2
6) chain A
residue 105
type
sequence C
description binding site for residue ZN A 602
source : AC2
7) chain A
residue 117
type
sequence H
description binding site for residue ZN A 602
source : AC2
8) chain A
residue 121
type
sequence C
description binding site for residue ZN A 602
source : AC2
9) chain B
residue 128
type
sequence C
description binding site for residue ZN B 601
source : AC3
10) chain B
residue 135
type
sequence C
description binding site for residue ZN B 601
source : AC3
11) chain B
residue 147
type
sequence H
description binding site for residue ZN B 601
source : AC3
12) chain B
residue 152
type
sequence H
description binding site for residue ZN B 601
source : AC3
13) chain B
residue 98
type
sequence C
description binding site for residue ZN B 602
source : AC4
14) chain B
residue 105
type
sequence C
description binding site for residue ZN B 602
source : AC4
15) chain B
residue 117
type
sequence H
description binding site for residue ZN B 602
source : AC4
16) chain B
residue 121
type
sequence C
description binding site for residue ZN B 602
source : AC4
17) chain A
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
18) chain A
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
19) chain A
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
20) chain A
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
21) chain B
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
22) chain B
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
23) chain B
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
24) chain B
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
25) chain A
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPA
SCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
26) chain B
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
27) chain A
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
28) chain A
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
29) chain A
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
30) chain A
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
31) chain B
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
32) chain B
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
33) chain B
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
34) chain B
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3

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