eF-site ID 4wv1-ABCDEF PDB Code 4wv1 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3 Classification TRANSFERASE/IMMUNE SYSTEM Compound Fibroblast growth factor receptor 2 Source Homo sapiens (Human) (4WV1) Sequence A:  DIQMTQSPSSLSASVGDRVTITCRASQDVDTSLAWYKQKP GKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQSTGHPQTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGEC B:  EVQLVESGGGLVQPGGSLRLSCAASGFTFTSTGISWVRQA PGKGLEWVGRTHLGDGSTNYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCARTYGIYDLYVDYTEYVMDYWGQG TLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSC C:  PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV ENEYGSINHTYHLDVVER D:  DIQMTQSPSSLSASVGDRVTITCRASQDVDTSLAWYKQKP GKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQSTGHPQTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGEC E:  EVQLVESGGGLVQPGGSLRLSCAASGFTFTSTGISWVRQA PGKGLEWVGRTHLGDGSTNYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCARTYGIYDLYVDYTEYVMDYWGQG TLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSC F:  PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV ENEYGSINHTYHLDVVER Description Functional site 1) chain F residue 225 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain F residue 238 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 225 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain C residue 238 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 6) chain A residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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