eF-site ID 4wru-A PDB Code 4wru Chain A click to enlarge Title Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with uracil, Form II Classification HYDROLASE Compound Uracil-DNA glycosylase Source Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (UNG_MYCTU) Sequence A:  RPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYL PAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSV APDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGV LLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPL VAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFG SRPFSRANELLVGMGAEPIDWRLP Description Functional site 1) chain A residue 67 type sequence Q description binding site for residue URA A 301 source : AC1 2) chain A residue 68 type sequence D description binding site for residue URA A 301 source : AC1 3) chain A residue 70 type sequence Y description binding site for residue URA A 301 source : AC1 4) chain A residue 80 type sequence S description binding site for residue URA A 301 source : AC1 5) chain A residue 81 type sequence F description binding site for residue URA A 301 source : AC1 6) chain A residue 127 type sequence N description binding site for residue URA A 301 source : AC1 7) chain A residue 191 type sequence H description binding site for residue URA A 301 source : AC1 8) chain A residue 70 type sequence Y description binding site for residue CL A 302 source : AC2 9) chain A residue 93 type sequence S description binding site for residue CL A 302 source : AC2 10) chain A residue 67 type sequence Q description binding site for residue GOL A 303 source : AC3 11) chain A residue 68 type sequence D description binding site for residue GOL A 303 source : AC3 12) chain A residue 71 type sequence P description binding site for residue GOL A 303 source : AC3 13) chain A residue 93 type sequence S description binding site for residue GOL A 303 source : AC3 14) chain A residue 137 type sequence P description binding site for residue GOL A 303 source : AC3 15) chain A residue 191 type sequence H description binding site for residue GOL A 303 source : AC3 16) chain A residue 61-70 type prosite sequence RVLIVGQDPY description U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVLIvGQDPY source prosite : PS00130 17) chain A residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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