eF-site ID 4wk0-ABC
PDB Code 4wk0
Chain A, B, C

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Title Metal Ion and Ligand Binding of Integrin
Classification CELL ADHESION/IMMUNE SYSTEM
Compound Integrin alpha-5
Source (4WK0)
Sequence A:  FNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAP
KANTSQPGVLQGGAVYLCPWGAQCTPIEFDSKGSRLLESS
LSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRT
EKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGY
CQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAES
YYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGD
DTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMAS
YFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGR
VYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQ
DGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQ
PLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKA
VVYRGRPVV
B:  NRCLKANAKSCGECIQAGPNCGWCTNSTFLTSARCDDLEA
LKKKGCPPDDIENPRGSKDIKKNKNVTNLKPEDITQIQPQ
QLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKD
DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYIS
TTPAKLRNPCTSEQNCTTPFSYKNVLSLTNKGEVFNELVG
KQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFS
TDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYP
SIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAV
GTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISY
KSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPK
KDSDSFKIRPLGFTEEVEVILQYICEC
C:  RGD
Description


Functional site

1) chain B
residue 132
type BINDING
sequence S
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 229
type BINDING
sequence E
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI1

3) chain B
residue 386
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI10

4) chain B
residue 134
type BINDING
sequence S
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 301
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 360
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

7) chain A
residue 362
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

8) chain A
residue 364
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

9) chain A
residue 366
type BINDING
sequence Y
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 368
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

11) chain A
residue 424
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 426
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 428
type BINDING
sequence N
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 430
type BINDING
sequence Y
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 241
type BINDING
sequence S
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 432
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 243
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 245
type BINDING
sequence T
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 247
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 293
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 295
type BINDING
sequence N
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 297
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 299
type BINDING
sequence L
description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI2

24) chain B
residue 137
type BINDING
sequence D
description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI3

25) chain B
residue 138
type BINDING
sequence D
description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI3

26) chain B
residue 342
type BINDING
sequence A
description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI3

27) chain B
residue 169
type BINDING
sequence E
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI4

28) chain A
residue 141
type BINDING
sequence N
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI4

29) chain A
residue 275
type BINDING
sequence N
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4
source Swiss-Prot : SWS_FT_FI4

30) chain B
residue 224
type BINDING
sequence N
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI5

31) chain B
residue 226
type BINDING
sequence D
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI5

32) chain B
residue 228
type BINDING
sequence P
description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI5

33) chain B
residue 30
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

34) chain B
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

35) chain B
residue 77
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

36) chain B
residue 192
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI7

37) chain B
residue 249
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI8

38) chain B
residue 343
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI9

39) chain B
residue 397
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
source Swiss-Prot : SWS_FT_FI9


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