eF-site ID 4wk0-ABC PDB Code 4wk0 Chain A, B, C click to enlarge Title Metal Ion and Ligand Binding of Integrin Classification CELL ADHESION/IMMUNE SYSTEM Compound Integrin alpha-5 Source (4WK0) Sequence A:  FNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAP KANTSQPGVLQGGAVYLCPWGAQCTPIEFDSKGSRLLESS LSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRT EKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGY CQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAES YYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGD DTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMAS YFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGR VYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQ DGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQ PLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKA VVYRGRPVV B:  NRCLKANAKSCGECIQAGPNCGWCTNSTFLTSARCDDLEA LKKKGCPPDDIENPRGSKDIKKNKNVTNLKPEDITQIQPQ QLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKD DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYIS TTPAKLRNPCTSEQNCTTPFSYKNVLSLTNKGEVFNELVG KQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFS TDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYP SIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAV GTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISY KSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPK KDSDSFKIRPLGFTEEVEVILQYICEC C:  RGD Description Functional site 1) chain B residue 132 type BINDING sequence S description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI1 2) chain B residue 229 type BINDING sequence E description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI1 3) chain B residue 386 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI10 4) chain B residue 134 type BINDING sequence S description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 301 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 360 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 362 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 364 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 366 type BINDING sequence Y description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 368 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 424 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 426 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 428 type BINDING sequence N description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 430 type BINDING sequence Y description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 241 type BINDING sequence S description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 432 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 243 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 245 type BINDING sequence T description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 247 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 293 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 295 type BINDING sequence N description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 297 type BINDING sequence D description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 299 type BINDING sequence L description in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 137 type BINDING sequence D description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI3 25) chain B residue 138 type BINDING sequence D description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI3 26) chain B residue 342 type BINDING sequence A description in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI3 27) chain B residue 169 type BINDING sequence E description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 141 type BINDING sequence N description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI4 29) chain A residue 275 type BINDING sequence N description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 224 type BINDING sequence N description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI5 31) chain B residue 226 type BINDING sequence D description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI5 32) chain B residue 228 type BINDING sequence P description in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI5 33) chain B residue 30 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 34) chain B residue 74 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 35) chain B residue 77 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 36) chain B residue 192 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI7 37) chain B residue 249 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI8 38) chain B residue 343 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI9 39) chain B residue 397 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD source Swiss-Prot : SWS_FT_FI9

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