eF-site ID 4w5r-ABD PDB Code 4w5r Chain A, B, D click to enlarge Title The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target) Classification HYDROLASE/RNA Compound Protein argonaute-2 Source null (4W5R) Sequence A:  AFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDI KPEKCPRRVNREIVEHMVQHFKTQIFRKPVFDGRKNLYTA MPLPIGRDKVELEVTLPIFKVSIKWVSCVSLQALHDALSG RLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCS NPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQP VIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEI KRKYRVCNVTRRPASHQTFPLVECTVAQYFKDRHKLVLRY PHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS TMIRATARSAPDRQEEISKLMRSADFNTDPYVREFGIMVK DEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQF HTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAG MPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVIL PGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSN LCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPP AGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDL AAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHH ELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNE RVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRP SHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAP AYYAHLVAFRARYHLVDKEGRDHQALAKAVQVHQDTLRTM YFA B:  UUCACAUUGUU D:  AAUGUGAAA Description Functional site 1) chain A residue 184 type sequence A description binding site for residue IPA A 901 source : AC1 2) chain A residue 197 type sequence E description binding site for residue IPA A 901 source : AC1 3) chain A residue 227 type sequence A description binding site for residue IPA A 901 source : AC1 4) chain A residue 348 type sequence A description binding site for residue IPA A 901 source : AC1 5) chain A residue 654 type sequence Y description binding site for residue IPA A 901 source : AC1 6) chain A residue 658 type sequence R description binding site for residue IPA A 901 source : AC1 7) chain A residue 580 type sequence P description binding site for residue IPA A 902 source : AC2 8) chain A residue 581 type sequence Q description binding site for residue IPA A 902 source : AC2 9) chain A residue 583 type sequence R description binding site for residue IPA A 902 source : AC2 10) chain A residue 584 type sequence P description binding site for residue IPA A 902 source : AC2 11) chain A residue 588 type sequence Q description binding site for residue IPA A 902 source : AC2 12) chain A residue 650 type sequence L description binding site for residue IPH A 903 source : AC3 13) chain A residue 654 type sequence Y description binding site for residue IPH A 903 source : AC3 14) chain A residue 695 type sequence E description binding site for residue IPH A 903 source : AC3 15) chain A residue 698 type sequence Y description binding site for residue IPH A 903 source : AC3 16) chain A residue 587 type sequence F description binding site for residue IPH A 904 source : AC4 17) chain A residue 589 type sequence Q description binding site for residue IPH A 904 source : AC4 18) chain A residue 591 type sequence V description binding site for residue IPH A 904 source : AC4 19) chain A residue 620 type sequence A description binding site for residue IPH A 904 source : AC4 20) chain A residue 653 type sequence F description binding site for residue IPH A 904 source : AC4 21) chain A residue 537 type sequence D description binding site for residue IPH A 905 source : AC5 22) chain A residue 541 type sequence G description binding site for residue IPH A 905 source : AC5 23) chain A residue 542 type sequence M description binding site for residue IPH A 905 source : AC5 24) chain A residue 543 type sequence A description binding site for residue IPH A 905 source : AC5 25) chain A residue 570 type sequence K description binding site for residue IPH A 905 source : AC5 26) chain A residue 852 type sequence T description binding site for residue IPH A 905 source : AC5 27) chain A residue 855 type sequence T description binding site for residue IPH A 905 source : AC5 28) chain A residue 857 type sequence Y description binding site for residue IPH A 905 source : AC5 29) chain A residue 597 type sequence D description binding site for residue MG A 906 source : AC6 30) chain A residue 598 type sequence V description binding site for residue MG A 906 source : AC6 31) chain D residue 6 type sequence U description binding site for residue MG D 101 source : AC7 32) chain A residue 597 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 669 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 807 type BINDING sequence H description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 700 type MOD_RES sequence P description 4-hydroxyproline => ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:18690212 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 387 type MOD_RES sequence D description Phosphoserine => ECO:0000269|PubMed:23603119, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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