eF-site ID 4uxd-ABCD PDB Code 4uxd Chain A, B, C, D click to enlarge Title 2-keto 3-deoxygluconate aldolase from Picrophilus torridus Classification LYASE Compound 2-DEHYDRO-3-DEOXY-D-GLUCONATE/2-DEHYDRO-3-DEOXY-PHOSPHOGLUCONATE ALDOLASE Source (KDGA_PICTO) Sequence A:  MYKGIVCPMITPLDAHGNIDYNATNILIKYLEGINVDYLF PMGSTGVFPYFTLKERKDFLKFVRENSKKPIMAGVGSSSI NEVNELMKFSMDIGIEAAVLMPPYYIKLNQEAIYHYYKEI LSSNDMDLLIYNIPQFTNKIDPETVKNLKSEFSSVKGVKD SSADIRGFMEMLSLSDDDFAVFQGQDDLLFTSLELGASGG VCGTTNFSDGIVRLYHEYKNNREMALKIEKNDVIPLMKKL GKYQFPNAYYEYFYKKNNINGGYRPPMYRVGIEI B:  MYKGIVCPMITPLDAHGNIDYNATNILIKYLEGINVDYLF PMGSTGVFPYFTLKERKDFLKFVRENSKKPIMAGVGSSSI NEVNELMKFSMDIGIEAAVLMPPYYIKLNQEAIYHYYKEI LSSNDMDLLIYNIPQFTNKIDPETVKNLKSEFSSVKGVKD SSADIRGFMEMLSLSDDDFAVFQGQDDLLFTSLELGASGG VCGTTNFSDGIVRLYHEYKNNREMALKIEKNDVIPLMKKL GKYQFPNAYYEYFYKKNNINGGYRPPMYRVGIEI C:  MYKGIVCPMITPLDAHGNIDYNATNILIKYLEGINVDYLF PMGSTGVFPYFTLKERKDFLKFVRENSKKPIMAGVGSSSI NEVNELMKFSMDIGIEAAVLMPPYYIKLNQEAIYHYYKEI LSSNDMDLLIYNIPQFTNKIDPETVKNLKSEFSSVKGVKD SSADIRGFMEMLSLSDDDFAVFQGQDDLLFTSLELGASGG VCGTTNFSDGIVRLYHEYKNNREMALKIEKNDVIPLMKKL GKYQFPNAYYEYFYKKNNINGGYRPPMYRVGIEI D:  MYKGIVCPMITPLDAHGNIDYNATNILIKYLEGINVDYLF PMGSTGVFPYFTLKERKDFLKFVRENSKKPIMAGVGSSSI NEVNELMKFSMDIGIEAAVLMPPYYIKLNQEAIYHYYKEI LSSNDMDLLIYNIPQFTNKIDPETVKNLKSEFSSVKGVKD SSADIRGFMEMLSLSDDDFAVFQGQDDLLFTSLELGASGG VCGTTNFSDGIVRLYHEYKNNREMALKIEKNDVIPLMKKL GKYQFPNAYYEYFYKKNNINGGYRPPMYRVGIEI Description Functional site 1) chain A residue 8 type sequence P description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 2) chain A residue 40 type sequence F description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 3) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 4) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 5) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 6) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 7) chain A residue 201 type sequence V description BINDING SITE FOR RESIDUE GOL A 1275 source : AC1 8) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 9) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 10) chain A residue 185 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 11) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 12) chain A residue 201 type sequence V description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 13) chain A residue 202 type sequence C description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 14) chain A residue 203 type sequence G description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 15) chain A residue 249 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1276 source : AC2 16) chain A residue 135 type sequence Q description BINDING SITE FOR RESIDUE IPA A 1277 source : AC3 17) chain A residue 136 type sequence F description BINDING SITE FOR RESIDUE IPA A 1277 source : AC3 18) chain A residue 185 type sequence Q description BINDING SITE FOR RESIDUE IPA A 1277 source : AC3 19) chain A residue 245 type sequence F description BINDING SITE FOR RESIDUE IPA A 1277 source : AC3 20) chain B residue 8 type sequence P description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 21) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 22) chain B residue 44 type sequence S description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 23) chain B residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 24) chain B residue 131 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 25) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 26) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 27) chain B residue 201 type sequence V description BINDING SITE FOR RESIDUE GOL B 1275 source : AC4 28) chain B residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 29) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 30) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 31) chain B residue 201 type sequence V description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 32) chain B residue 202 type sequence C description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 33) chain B residue 203 type sequence G description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 34) chain B residue 237 type sequence M description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 35) chain B residue 249 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1276 source : AC5 36) chain B residue 135 type sequence Q description BINDING SITE FOR RESIDUE IPA B 1277 source : AC6 37) chain B residue 185 type sequence Q description BINDING SITE FOR RESIDUE IPA B 1277 source : AC6 38) chain C residue 8 type sequence P description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 39) chain C residue 40 type sequence F description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 40) chain C residue 43 type sequence G description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 41) chain C residue 44 type sequence S description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 42) chain C residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 43) chain C residue 131 type sequence Y description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 44) chain C residue 161 type sequence S description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 45) chain C residue 184 type sequence G description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 46) chain C residue 201 type sequence V description BINDING SITE FOR RESIDUE GOL C 1275 source : AC7 47) chain C residue 184 type sequence G description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 48) chain C residue 186 type sequence D description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 49) chain C residue 201 type sequence V description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 50) chain C residue 202 type sequence C description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 51) chain C residue 203 type sequence G description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 52) chain C residue 237 type sequence M description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 53) chain C residue 249 type sequence Y description BINDING SITE FOR RESIDUE EDO C 1276 source : AC8 54) chain C residue 133 type sequence I description BINDING SITE FOR RESIDUE PGE C 1277 source : AC9 55) chain C residue 136 type sequence F description BINDING SITE FOR RESIDUE PGE C 1277 source : AC9 56) chain C residue 185 type sequence Q description BINDING SITE FOR RESIDUE PGE C 1277 source : AC9 57) chain C residue 245 type sequence F description BINDING SITE FOR RESIDUE PGE C 1277 source : AC9 58) chain D residue 8 type sequence P description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 59) chain D residue 40 type sequence F description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 60) chain D residue 43 type sequence G description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 61) chain D residue 44 type sequence S description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 62) chain D residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 63) chain D residue 131 type sequence Y description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 64) chain D residue 161 type sequence S description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 65) chain D residue 184 type sequence G description BINDING SITE FOR RESIDUE GOL D 1275 source : BC1 66) chain D residue 184 type sequence G description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 67) chain D residue 186 type sequence D description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 68) chain D residue 201 type sequence V description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 69) chain D residue 202 type sequence C description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 70) chain D residue 203 type sequence G description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 71) chain D residue 237 type sequence M description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 72) chain D residue 249 type sequence Y description BINDING SITE FOR RESIDUE EDO D 1276 source : BC2 73) chain D residue 161 type sequence S description BINDING SITE FOR RESIDUE GOL D 1277 source : BC3 74) chain D residue 185 type sequence Q description BINDING SITE FOR RESIDUE GOL D 1277 source : BC3 75) chain D residue 245 type sequence F description BINDING SITE FOR RESIDUE GOL D 1277 source : BC3 76) chain A residue 14 type sequence D description BINDING SITE FOR RESIDUE EDO A 1278 source : BC4 77) chain A residue 18 type sequence N description BINDING SITE FOR RESIDUE EDO A 1278 source : BC4 78) chain D residue 187 type sequence D description BINDING SITE FOR RESIDUE EDO D 1278 source : BC5 79) chain D residue 234 type sequence I description BINDING SITE FOR RESIDUE EDO D 1278 source : BC5 80) chain D residue 238 type sequence K description BINDING SITE FOR RESIDUE EDO D 1278 source : BC5 81) chain D residue 19 type sequence I description BINDING SITE FOR RESIDUE EDO D 1279 source : BC6 82) chain D residue 20 type sequence D description BINDING SITE FOR RESIDUE EDO D 1279 source : BC6 83) chain D residue 21 type sequence Y description BINDING SITE FOR RESIDUE EDO D 1279 source : BC6 84) chain D residue 22 type sequence N description BINDING SITE FOR RESIDUE EDO D 1279 source : BC6 85) chain C residue 81 type sequence N description BINDING SITE FOR RESIDUE GOL D 1280 source : BC7 86) chain D residue 16 type sequence H description BINDING SITE FOR RESIDUE GOL D 1280 source : BC7 87) chain D residue 17 type sequence G description BINDING SITE FOR RESIDUE GOL D 1280 source : BC7 88) chain D residue 18 type sequence N description BINDING SITE FOR RESIDUE GOL D 1280 source : BC7 89) chain D residue 264 type sequence R description BINDING SITE FOR RESIDUE GOL D 1280 source : BC7 90) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 91) chain B residue 169 type sequence M description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 92) chain B residue 170 type sequence E description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 93) chain C residue 187 type sequence D description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 94) chain C residue 234 type sequence I description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 95) chain C residue 238 type sequence K description BINDING SITE FOR RESIDUE GOL C 1278 source : BC8 96) chain C residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL C 1279 source : BC9 97) chain C residue 110 type sequence Q description BINDING SITE FOR RESIDUE GOL C 1279 source : BC9 98) chain C residue 139 type sequence K description BINDING SITE FOR RESIDUE GOL C 1279 source : BC9 99) chain B residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL B 1278 source : CC1 100) chain B residue 110 type sequence Q description BINDING SITE FOR RESIDUE GOL B 1278 source : CC1 101) chain B residue 139 type sequence K description BINDING SITE FOR RESIDUE GOL B 1278 source : CC1 102) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE GOL B 1278 source : CC1 103) chain A residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL A 1279 source : CC2 104) chain A residue 110 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1279 source : CC2 105) chain A residue 139 type sequence K description BINDING SITE FOR RESIDUE GOL A 1279 source : CC2 106) chain D residue 107 type sequence K description BINDING SITE FOR RESIDUE GOL D 1281 source : CC3 107) chain D residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL D 1281 source : CC3 108) chain D residue 110 type sequence Q description BINDING SITE FOR RESIDUE GOL D 1281 source : CC3 109) chain D residue 139 type sequence K description BINDING SITE FOR RESIDUE GOL D 1281 source : CC3 110) chain A residue 105 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 111) chain A residue 135 type sequence Q description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 112) chain A residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 113) chain B residue 104 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 114) chain B residue 105 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 115) chain B residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 116) chain B residue 137 type sequence T description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 117) chain B residue 138 type sequence N description BINDING SITE FOR RESIDUE GOL B 1279 source : CC4 118) chain A residue 104 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 119) chain A residue 105 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 120) chain A residue 107 type sequence K description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 121) chain A residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 122) chain A residue 137 type sequence T description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 123) chain A residue 138 type sequence N description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 124) chain B residue 135 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 125) chain B residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL A 1280 source : CC5 126) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE GOL B 1280 source : CC6 127) chain B residue 142 type sequence P description BINDING SITE FOR RESIDUE GOL B 1280 source : CC6 128) chain B residue 167 type sequence G description BINDING SITE FOR RESIDUE GOL B 1280 source : CC6 129) chain B residue 170 type sequence E description BINDING SITE FOR RESIDUE GOL B 1280 source : CC6 130) chain B residue 171 type sequence M description BINDING SITE FOR RESIDUE GOL B 1280 source : CC6 131) chain C residue 135 type sequence Q description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 132) chain C residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 133) chain D residue 104 type sequence Y description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 134) chain D residue 105 type sequence Y description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 135) chain D residue 136 type sequence F description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 136) chain D residue 137 type sequence T description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 137) chain D residue 138 type sequence N description BINDING SITE FOR RESIDUE GOL D 1282 source : CC7 138) chain A residue 166 type sequence R description BINDING SITE FOR RESIDUE GOL A 1281 source : CC8 139) chain A residue 169 type sequence M description BINDING SITE FOR RESIDUE GOL A 1281 source : CC8 140) chain A residue 170 type sequence E description BINDING SITE FOR RESIDUE GOL A 1281 source : CC8 141) chain D residue 234 type sequence I description BINDING SITE FOR RESIDUE GOL A 1281 source : CC8 142) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 143) chain A residue 140 type sequence I description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 144) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 145) chain A residue 142 type sequence P description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 146) chain A residue 167 type sequence G description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 147) chain A residue 171 type sequence M description BINDING SITE FOR RESIDUE GOL A 1282 source : CC9 148) chain B residue 164 type sequence D description BINDING SITE FOR RESIDUE PEG B 1281 source : DC1 149) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE PEG B 1281 source : DC1 150) chain C residue 162 type sequence S description BINDING SITE FOR RESIDUE PEG B 1281 source : DC1 151) chain C residue 163 type sequence A description BINDING SITE FOR RESIDUE PEG B 1281 source : DC1 152) chain C residue 164 type sequence D description BINDING SITE FOR RESIDUE PEG B 1281 source : DC1 153) chain D residue 107 type sequence K description BINDING SITE FOR RESIDUE IPA D 1283 source : DC2 154) chain D residue 134 type sequence P description BINDING SITE FOR RESIDUE IPA D 1283 source : DC2 155) chain D residue 137 type sequence T description BINDING SITE FOR RESIDUE IPA D 1283 source : DC2 156) chain D residue 139 type sequence K description BINDING SITE FOR RESIDUE IPA D 1283 source : DC2 157) chain A residue 44 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 158) chain D residue 44 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 159) chain D residue 131 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 160) chain D residue 159 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 161) chain A residue 131 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 162) chain A residue 159 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 163) chain B residue 44 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 164) chain B residue 131 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 165) chain B residue 159 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 166) chain C residue 44 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 167) chain C residue 131 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 168) chain C residue 159 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 169) chain A residue 159 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 170) chain B residue 159 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 171) chain C residue 159 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 172) chain D residue 159 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 173) chain A residue 131-161 type prosite sequence YNIPQFTNKIDPETVKNLKSEFSSVKGVKDS description DHDPS_2 Dihydrodipicolinate synthase signature 2. YNIPqfTnk.IdpetvknlksefssVkGVKDS source prosite : PS00666 174) chain A residue 131 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 175) chain B residue 131 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 176) chain C residue 131 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 177) chain D residue 131 type SITE sequence Y description Proton shuttle => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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