eF-site ID 4uwf-A PDB Code 4uwf Chain A click to enlarge Title Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors Classification TRANSFERASE Compound PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 Source (PK3C3_HUMAN) Sequence A:  LKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTN QEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLE LLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKY ENFDDIKNGLEINSAEIDSSQIITSPLLEQDLCTFLISRA CKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRR FSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRES GNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRG IIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQ DQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQ FIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMD TYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFG YILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCY TAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQ DKFRLDLSDEEAVHYMQSLIDESVHALFAA Description Functional site 1) chain A residue 612 type sequence F description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 2) chain A residue 614 type sequence S description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 3) chain A residue 618 type sequence P description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 4) chain A residue 634 type sequence I description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 5) chain A residue 636 type sequence K description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 6) chain A residue 670 type sequence Y description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 7) chain A residue 682 type sequence M description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 8) chain A residue 683 type sequence Q description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 9) chain A residue 684 type sequence F description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 10) chain A residue 685 type sequence I description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 11) chain A residue 689 type sequence P description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 12) chain A residue 747 type sequence D description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 13) chain A residue 750 type sequence L description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 14) chain A residue 760 type sequence I description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 15) chain A residue 761 type sequence D description BINDING SITE FOR RESIDUE EUT A 4000 source : AC1 16) chain A residue 635-649 type prosite sequence FKHGDDLRQDQLILQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ source prosite : PS00915 17) chain A residue 728-748 type prosite sequence SCAGYCVITYILGVGDRHLDN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN source prosite : PS00916

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