eF-site ID 4uvx-AB PDB Code 4uvx Chain A, B click to enlarge Title Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-fluoro-1,2-dihydroisoquinolin-1-one Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 2) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 3) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 4) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 5) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 6) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC2 7) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC2 8) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC2 9) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC2 10) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC2 11) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 12) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 13) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 14) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 15) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 16) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 17) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 18) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 19) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 20) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 21) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 22) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 23) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 24) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 25) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC6 26) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2164 source : AC6 27) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC6 28) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC6 29) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 30) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 31) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 32) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 33) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 34) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 35) chain B residue 1033 type sequence S description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 36) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 37) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 38) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 39) chain B residue 1062 type sequence A description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 40) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 41) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 42) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 43) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE H2W B 2165 source : AC8 44) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 45) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 46) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 47) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 48) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 49) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 50) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 51) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 52) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 53) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 54) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 55) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 56) chain A residue 987 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 57) chain A residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 58) chain A residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 59) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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