eF-site ID 4uvx-A PDB Code 4uvx Chain A click to enlarge Title Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-fluoro-1,2-dihydroisoquinolin-1-one Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 2) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 3) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 4) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 5) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 6) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 7) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 8) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 9) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 10) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 11) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 12) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 13) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 14) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 15) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2164 source : AC5 16) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 17) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 18) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 19) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 20) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 21) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 22) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 23) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 24) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 25) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 26) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 27) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 28) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE H2W A 2166 source : AC9 29) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 30) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 31) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 32) chain A residue 987 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 33) chain A residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 34) chain A residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 35) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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