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eF-site ID
|
4uv7-AHL |
PDB Code
|
4uv7 |
Chain
|
A, H, L |
|
click to enlarge
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Title
|
The complex structure of extracellular domain of EGFR and GC1118A |
Classification
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TRANSFERASE |
Compound
|
EPIDERMAL GROWTH FACTOR RECEPTOR |
Source
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(4UV7) |
|
Sequence
|
A: |
LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGN
LEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENL
QIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEIL
HGAVRFSNNPALCNVESIQWRDIVSSQKCDPSCPNGSCWG
AGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT
GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNP
EGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEED
GVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN
CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEI
TGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVV
SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF
GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPR
DCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPE
CLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG
ENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCP
|
H: |
EVQLVESGGGVVQPGGSLRLSCAASGFTFSDYDMSWIRQA
PGKGLEWVSGILGGSERSYYRDSVKGRFTISRDNSRKTLY
LQMNSLRAEDTAVYYCARHGSPGYTLYAWDYWGQGTTVTV
SSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC
NVNHKPSNTKVDKKAEPK
|
L: |
DIVMTQTPLSLPVTPGEPASISCRSNQDLTHSNGNTYLEW
YLQKPGQSPRLLIYKVSNRFSGVPDRFSGSGAGTDFTLRI
SRVEAEDVGVYYCMQGTHWPWTFGQGTKVDIKRTVAAPSV
FIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALN
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACE
VTHQGLSSPVTKSFNR
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Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
205 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0000269|PubMed:21487020
|
source |
Swiss-Prot : SWS_FT_FI2
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2)
|
chain |
A |
residue |
32 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
3)
|
chain |
A |
residue |
49 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:20837704, ECO:0007744|PDB:3NJP
|
source |
Swiss-Prot : SWS_FT_FI4
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|
4)
|
chain |
A |
residue |
104 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:8962717
|
source |
Swiss-Prot : SWS_FT_FI5
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5)
|
chain |
A |
residue |
172 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
6)
|
chain |
A |
residue |
328 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
7)
|
chain |
A |
residue |
337 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7
|
source |
Swiss-Prot : SWS_FT_FI9
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|
8)
|
chain |
A |
residue |
389 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP
|
source |
Swiss-Prot : SWS_FT_FI10
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|
9)
|
chain |
A |
residue |
420 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
source |
Swiss-Prot : SWS_FT_FI11
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|
10)
|
chain |
A |
residue |
504 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
source |
Swiss-Prot : SWS_FT_FI12
|
|
11)
|
chain |
A |
residue |
544 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9
|
source |
Swiss-Prot : SWS_FT_FI13
|
|
12)
|
chain |
A |
residue |
579 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9
|
source |
Swiss-Prot : SWS_FT_FI14
|
|
13)
|
chain |
A |
residue |
599 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000305|PubMed:12731890
|
source |
Swiss-Prot : SWS_FT_FI15
|
|
14)
|
chain |
L |
residue |
197-203 |
type |
prosite |
sequence |
YACEVTH
|
description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
source |
prosite : PS00290
|
|
15)
|
chain |
H |
residue |
203-209 |
type |
prosite |
sequence |
YICNVNH
|
description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
source |
prosite : PS00290
|
|
|
|