eF-site ID 4uuu-AB PDB Code 4uuu Chain A, B click to enlarge Title 1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in complex with SAM Classification LYASE Compound CYSTATHIONINE BETA-SYNTHASE Source Homo sapiens (Human) (CBS_HUMAN) Sequence A:  NLYFQSMKPWWWHLRVQELGLSAPLTVLPTITCGHTIEIL REKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQ VGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQQRQ MVFGVVTAIDLLNFVAA B:  GVDLGTENLYFQSMKPWWWHLRVQELGLSAPLTVLPTITC GHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAG KVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALV VHEQQRQMVFGVVTAIDLLNFVAAQE Description (1)  CYSTATHIONINE BETA-SYNTHASE (E.C.4.2.1.22) Functional site 1) chain A residue 442 type sequence G description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 2) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 3) chain B residue 421 type sequence A description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 4) chain B residue 422 type sequence P description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 5) chain B residue 423 type sequence L description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 6) chain B residue 442 type sequence G description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 7) chain B residue 443 type sequence F description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 8) chain B residue 444 type sequence D description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 9) chain B residue 445 type sequence Q description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 10) chain B residue 446 type sequence A description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 11) chain B residue 533 type sequence V description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 12) chain B residue 535 type sequence T description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 13) chain B residue 537 type sequence I description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 14) chain B residue 538 type sequence D description BINDING SITE FOR RESIDUE SAM B 1548 source : AC1 15) chain A residue 422 type sequence P description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 16) chain A residue 423 type sequence L description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 17) chain A residue 442 type sequence G description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 18) chain A residue 443 type sequence F description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 19) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 20) chain A residue 445 type sequence Q description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 21) chain A residue 533 type sequence V description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 22) chain A residue 535 type sequence T description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 23) chain A residue 537 type sequence I description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 24) chain A residue 538 type sequence D description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 25) chain B residue 442 type sequence G description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 26) chain B residue 444 type sequence D description BINDING SITE FOR RESIDUE SAM A 1546 source : AC2 27) chain A residue -3 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1549 source : AC3 28) chain A residue 421 type sequence A description BINDING SITE FOR RESIDUE EDO B 1549 source : AC3 29) chain A residue 530 type sequence V description BINDING SITE FOR RESIDUE EDO B 1549 source : AC3 30) chain A residue 531 type sequence F description BINDING SITE FOR RESIDUE EDO B 1549 source : AC3 31) chain B residue 526 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1549 source : AC3 32) chain A residue 419 type sequence L description BINDING SITE FOR RESIDUE EDO A 1547 source : AC4 33) chain A residue 420 type sequence S description BINDING SITE FOR RESIDUE EDO A 1547 source : AC4 34) chain A residue 538 type sequence D description BINDING SITE FOR RESIDUE EDO A 1547 source : AC4 35) chain B residue 463 type sequence N description BINDING SITE FOR RESIDUE EDO B 1550 source : AC5 36) chain B residue 467 type sequence S description BINDING SITE FOR RESIDUE EDO B 1550 source : AC5 37) chain B residue 472 type sequence K description BINDING SITE FOR RESIDUE EDO B 1550 source : AC5 38) chain B residue 482 type sequence V description BINDING SITE FOR RESIDUE EDO B 1550 source : AC5 39) chain B residue 483 type sequence I description BINDING SITE FOR RESIDUE EDO B 1550 source : AC5 40) chain A residue 513 type sequence H description BINDING SITE FOR RESIDUE EDO B 1551 source : AC6 41) chain A residue 530 type sequence V description BINDING SITE FOR RESIDUE EDO B 1551 source : AC6 42) chain B residue 452 type sequence A description BINDING SITE FOR RESIDUE EDO B 1551 source : AC6 43) chain B residue 528 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1551 source : AC6 44) chain A residue 493 type sequence T description BINDING SITE FOR RESIDUE EDO A 1548 source : AC7 45) chain A residue 513 type sequence H description BINDING SITE FOR RESIDUE EDO A 1548 source : AC7 46) chain A residue 514 type sequence E description BINDING SITE FOR RESIDUE EDO A 1548 source : AC7 47) chain A residue 410 type sequence W description BINDING SITE FOR RESIDUE EDO A 1549 source : AC8 48) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE EDO A 1549 source : AC8 49) chain A residue 515 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1550 source : AC9 50) chain B residue 453 type sequence G description BINDING SITE FOR RESIDUE EDO A 1550 source : AC9 51) chain B residue 529 type sequence M description BINDING SITE FOR RESIDUE EDO A 1550 source : AC9 52) chain B residue 530 type sequence V description BINDING SITE FOR RESIDUE EDO A 1550 source : AC9 53) chain A residue 436 type sequence E description BINDING SITE FOR RESIDUE EDO B 1552 source : BC1 54) chain A residue 440 type sequence E description BINDING SITE FOR RESIDUE EDO B 1552 source : BC1 55) chain B residue 472 type sequence K description BINDING SITE FOR RESIDUE EDO B 1552 source : BC1 56) chain A residue 542 type sequence F description BINDING SITE FOR RESIDUE EDO A 1551 source : BC2 57) chain A residue 545 type sequence A description BINDING SITE FOR RESIDUE EDO A 1551 source : BC2 58) chain A residue 439 type sequence R description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 59) chain A residue 440 type sequence E description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 60) chain A residue 441 type sequence K description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 61) chain A residue 442 type sequence G description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 62) chain B residue 441 type sequence K description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 63) chain B residue 442 type sequence G description BINDING SITE FOR RESIDUE EDO A 1552 source : BC3 64) chain A residue 408 type sequence W description BINDING SITE FOR RESIDUE EDO A 1553 source : BC4 65) chain A residue 543 type sequence V description BINDING SITE FOR RESIDUE EDO A 1553 source : BC4 66) chain B residue -14 type sequence G description BINDING SITE FOR RESIDUE EDO A 1553 source : BC4 67) chain B residue 407 type sequence P description BINDING SITE FOR RESIDUE EDO B 1553 source : BC5 68) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE EDO B 1553 source : BC5 69) chain B residue 498 type sequence R description BINDING SITE FOR RESIDUE EDO B 1553 source : BC5 70) chain B residue 543 type sequence V description BINDING SITE FOR RESIDUE EDO B 1553 source : BC5 71) chain B residue 547 type sequence E description BINDING SITE FOR RESIDUE EDO B 1553 source : BC5

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