eF-site ID 4ury-RS PDB Code 4ury Chain R, S click to enlarge Title The crystal structure of H-Ras and SOS in complex with ligands Classification SIGNALING PROTEIN Compound GTPASE HRAS Source Homo sapiens (Human) (SOS1_HUMAN) Sequence R:  HMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDS YRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFL CVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCD LAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTL VREIRQH S:  QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGT VIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLII ERFEIPELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFER DAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQS SPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLY RAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVS AMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYL AKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELI NFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNP MGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLK SPGVRPSNP Description Functional site 1) chain R residue 5 type sequence K description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 2) chain R residue 6 type sequence L description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 3) chain R residue 54 type sequence D description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 4) chain R residue 56 type sequence L description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 5) chain R residue 71 type sequence Y description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 6) chain R residue 74 type sequence T description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 7) chain S residue 908 type sequence S description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 8) chain S residue 909 type sequence E description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 9) chain S residue 910 type sequence D description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 10) chain S residue 911 type sequence H description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 11) chain S residue 912 type sequence Y description BINDING SITE FOR RESIDUE RV1 R 1167 source : AC1 12) chain S residue 759 type sequence P description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 13) chain S residue 782 type sequence I description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 14) chain S residue 786 type sequence R description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 15) chain S residue 865 type sequence L description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 16) chain S residue 1040 type sequence V description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 17) chain S residue 1041 type sequence R description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 18) chain S residue 1042 type sequence P description BINDING SITE FOR RESIDUE RV1 S 2046 source : AC2 19) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720 20) chain R residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI2 21) chain R residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI3 22) chain R residue 118 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:9020151 source Swiss-Prot : SWS_FT_FI4 23) chain R residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 source Swiss-Prot : SWS_FT_FI5 24) chain R residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 25) chain R residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 26) chain R residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 27) chain R residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 28) chain R residue 145 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1

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