eF-site ID 4ura-AB PDB Code 4ura Chain A, B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 14a Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  ESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAG LAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFT QYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWK NLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMT LISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGF NCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRK FQPERYKLWKAGKDNTVIDHTLPTPEAAE B:  PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVP PKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQK KAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNP PIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIE GVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLM LKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAEST NFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERY KLWKAGKDNTVIDHTLPTPEAAEF Description (1)  LYSINE-SPECIFIC DEMETHYLASE 4A (E.C.1.14.11.-) Functional site 1) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE NI A 2501 source : AC1 2) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE NI A 2501 source : AC1 3) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE NI A 2501 source : AC1 4) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 2502 source : AC2 5) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 2502 source : AC2 6) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 2502 source : AC2 7) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 2502 source : AC2 8) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 9) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 10) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 11) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 12) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 13) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 14) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE LEL A 4000 source : AC3 15) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE NI B 2501 source : AC4 16) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE NI B 2501 source : AC4 17) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE NI B 2501 source : AC4 18) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 2502 source : AC5 19) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 2502 source : AC5 20) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 2502 source : AC5 21) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 2502 source : AC5 22) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 23) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 24) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 25) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 26) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 27) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 28) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 29) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE LEL B 4000 source : AC6 30) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO A 1353 source : AC7 31) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1353 source : AC7 32) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO A 1353 source : AC7 33) chain A residue 196 type sequence S description BINDING SITE FOR RESIDUE EDO A 1353 source : AC7 34) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE EDO A 1353 source : AC7 35) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC8 36) chain A residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC8 37) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC8 38) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC8 39) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC8 40) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC9 41) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC9 42) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC9 43) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC9 44) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC9 45) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 46) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 47) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 48) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 49) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 50) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 51) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 52) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 53) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 54) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 55) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 56) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 57) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 58) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 59) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 62) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 71) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 72) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 73) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 74) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 75) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 76) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 77) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 78) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4

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