eF-site ID 4uim-ABCDEFHL PDB Code 4uim Chain A, B, C, D, E, F, H, L click to enlarge Title crystal structure of quinine-dependent Fab 314.3 Classification IMMUNE SYSTEM Compound FAB 314.3 Source ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_SCIENTIFIC: MUS MUSCULUS; Sequence A:  EVQLQQSGTVLARPGASVKMSCEASGYTFTSYWMHWLKKR PGQGLEWIGTIYPGNSDSSYNQRFKGKAKLTAVTSTSTAY MELSSLTNEDSAVYYCTRERGLYYGGRSFDYWGQGTTLTV SSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVT VTWNSGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSE TVTCNVAHPASSTKVDKKIVPRDC B:  DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKP DGTVKLLIYYTSKLHSGVPSRFSGSGSGTDYSLTISNLEQ EDVANYFCQQGNSLPPTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC C:  EVQLQQSGTVLARPGASVKMSCEASGYTFTSYWMHWLKKR PGQGLEWIGTIYPGNSDSSYNQRFKGKAKLTAVTSTSTAY MELSSLTNEDSAVYYCTRERGLYYGGRSFDYWGQGTTLTV SSAKTTPPSVYPLAPGSNSMVTLGCLVKGYFPEPVTVTWN SGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSETVTC NVAHPASSTKVDKKIVPRDCG D:  DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKP DGTVKLLIYYTSKLHSGVPSRFSGSGSGTDYSLTISNLEQ EDVANYFCQQGNSLPPTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC E:  EVQLQQSGTVLARPGASVKMSCEASGYTFTSYWMHWLKKR PGQGLEWIGTIYPGNSDSSYNQRFKGKAKLTAVTSTSTAY MELSSLTNEDSAVYYCTRERGLYYGGRSFDYWGQGTTLTV SSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVT VTWNSGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSE TVTCNVAHPASSTKVDKKIVPRDC F:  DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKP DGTVKLLIYYTSKLHSGVPSRFSGSGSGTDYSLTISNLEQ EDVANYFCQQGNSLPPTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC H:  EVQLQQSGTVLARPGASVKMSCEASGYTFTSYWMHWLKKR PGQGLEWIGTIYPGNSDSSYNQRFKGKAKLTAVTSTSTAY MELSSLTNEDSAVYYCTRERGLYYGGRSFDYWGQGTTLTV SSAKTTPPSVYPLAPGSTNSMVTLGCLVKGYFPEPVTVTW NSGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSETVT CNVAHPASSTKVDKKIVPRDCG L:  DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKP DGTVKLLIYYTSKLHSGVPSRFSGSGSGTDYSLTISNLEQ EDVANYFCQQGNSLPPTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC Description Functional site 1) chain B residue 182 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1215 source : AC1 2) chain B residue 184 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1215 source : AC1 3) chain B residue 188 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1215 source : AC1 4) chain H residue 100 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1215 source : AC1 5) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 6) chain B residue 188 type sequence R description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 7) chain B residue 189 type sequence H description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 8) chain H residue 27 type sequence Y description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 9) chain H residue 28 type sequence T description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 10) chain H residue 32 type sequence Y description BINDING SITE FOR RESIDUE SO4 H 1226 source : AC2 11) chain B residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

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