eF-site ID 4uhi-D PDB Code 4uhi Chain D click to enlarge Title HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP Classification OXIDOREDUCTASE Compound STEROL 14-ALPHA DEMETHYLASE Source (CP51A_HUMAN) Sequence D:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS Description (1)  STEROL 14-ALPHA DEMETHYLASE (E.C.1.14.13.70) Functional site 1) chain D residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 2) chain D residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 3) chain D residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 4) chain D residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 5) chain D residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 6) chain D residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 7) chain D residue 312 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 8) chain D residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 9) chain D residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 10) chain D residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 11) chain D residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 12) chain D residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 13) chain D residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 14) chain D residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 15) chain D residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 16) chain D residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 17) chain D residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 18) chain D residue 450 type sequence I description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 19) chain D residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 20) chain D residue 455 type sequence A description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 21) chain D residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 22) chain D residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 23) chain D residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 24) chain D residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 25) chain D residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 26) chain D residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 27) chain D residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 28) chain D residue 308 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 29) chain D residue 310 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 30) chain D residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 31) chain D residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 32) chain D residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 33) chain D residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 34) chain D residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 35) chain D residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 36) chain D residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 37) chain D residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 38) chain D residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 39) chain D residue 240 type sequence L description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 40) chain D residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 41) chain D residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 42) chain D residue 488 type sequence I description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 43) chain D residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1

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