eF-site ID 4uhi-ABCD PDB Code 4uhi Chain A, B, C, D click to enlarge Title HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP Classification OXIDOREDUCTASE Compound STEROL 14-ALPHA DEMETHYLASE Source (CP51A_HUMAN) Sequence A:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS B:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS C:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS D:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS Description Functional site 1) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 2) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 3) chain A residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 4) chain A residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 5) chain A residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 6) chain A residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 7) chain A residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 8) chain A residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 9) chain A residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 10) chain A residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 11) chain A residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 12) chain A residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 13) chain A residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 14) chain A residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 15) chain A residue 450 type sequence I description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 16) chain A residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 17) chain A residue 455 type sequence A description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 18) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 19) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 20) chain A residue 135 type sequence T description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 21) chain A residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 22) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 23) chain A residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 24) chain A residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 25) chain A residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 26) chain A residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 27) chain A residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 28) chain A residue 308 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 29) chain A residue 310 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 30) chain A residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 31) chain A residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 32) chain A residue 487 type sequence M description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 33) chain A residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 34) chain A residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 35) chain A residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 36) chain A residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 37) chain A residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 38) chain A residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 39) chain A residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 40) chain A residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 41) chain A residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 42) chain B residue 245 type sequence L description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 43) chain B residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 44) chain B residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 45) chain B residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 46) chain B residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 47) chain B residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 48) chain B residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 49) chain B residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 50) chain B residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 51) chain B residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 52) chain B residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 53) chain B residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 54) chain B residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 55) chain B residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 56) chain B residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 57) chain B residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 58) chain B residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 59) chain B residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM B 540 source : AC4 60) chain B residue 131 type sequence Y description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 61) chain B residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 62) chain B residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 63) chain B residue 144 type sequence A description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 64) chain B residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 65) chain B residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 66) chain B residue 235 type sequence S description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 67) chain B residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 68) chain B residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 69) chain B residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 70) chain B residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 71) chain B residue 308 type sequence L description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 72) chain B residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 73) chain B residue 315 type sequence T description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 74) chain B residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV B 580 source : AC5 75) chain A residue 245 type sequence L description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 76) chain A residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 77) chain A residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 78) chain B residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 79) chain B residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 80) chain B residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 81) chain B residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 82) chain B residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 83) chain B residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 84) chain B residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 85) chain B residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 86) chain B residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 87) chain C residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 88) chain C residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 89) chain C residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 90) chain C residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 91) chain C residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 92) chain C residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 93) chain C residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 94) chain C residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 95) chain C residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 96) chain C residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 97) chain C residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 98) chain C residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 99) chain C residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 100) chain C residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 101) chain C residue 450 type sequence I description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 102) chain C residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 103) chain C residue 455 type sequence A description BINDING SITE FOR RESIDUE HEM C 540 source : AC7 104) chain C residue 131 type sequence Y description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 105) chain C residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 106) chain C residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 107) chain C residue 144 type sequence A description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 108) chain C residue 152 type sequence F description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 109) chain C residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 110) chain C residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 111) chain C residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 112) chain C residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 113) chain C residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 114) chain C residue 310 type sequence L description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 115) chain C residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 116) chain C residue 315 type sequence T description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 117) chain C residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV C 580 source : AC8 118) chain C residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 119) chain C residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 120) chain C residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 121) chain C residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 122) chain C residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 123) chain C residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 124) chain C residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 125) chain C residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 126) chain C residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 127) chain C residue 488 type sequence I description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 128) chain D residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 129) chain D residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV C 600 source : AC9 130) chain D residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 131) chain D residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 132) chain D residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 133) chain D residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 134) chain D residue 312 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 135) chain D residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 136) chain D residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 137) chain D residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 138) chain D residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 139) chain D residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 140) chain D residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 141) chain D residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 142) chain D residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 143) chain D residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 144) chain D residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 145) chain D residue 450 type sequence I description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 146) chain D residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 147) chain D residue 455 type sequence A description BINDING SITE FOR RESIDUE HEM D 540 source : BC1 148) chain D residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 149) chain D residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 150) chain D residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 151) chain D residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 152) chain D residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 153) chain D residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 154) chain D residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 155) chain D residue 308 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 156) chain D residue 310 type sequence L description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 157) chain D residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 158) chain D residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV D 580 source : BC2 159) chain C residue 245 type sequence L description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 160) chain C residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 161) chain C residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 162) chain D residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 163) chain D residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 164) chain D residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 165) chain D residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 166) chain D residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 167) chain D residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 168) chain D residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 169) chain D residue 240 type sequence L description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 170) chain D residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 171) chain D residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 172) chain D residue 488 type sequence I description BINDING SITE FOR RESIDUE VFV D 600 source : BC3 173) chain A residue 442-451 type prosite sequence FGAGRHRCIG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGRHRCIG source prosite : PS00086 174) chain A residue 204-209 type prosite sequence LTASHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTASHC source prosite : PS00134 175) chain A residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1 176) chain B residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1 177) chain C residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1 178) chain D residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1

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