eF-site ID 4uhi-A PDB Code 4uhi Chain A click to enlarge Title HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP Classification OXIDOREDUCTASE Compound STEROL 14-ALPHA DEMETHYLASE Source (CP51A_HUMAN) Sequence A:  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTM VGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREI KDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKR RS Description Functional site 1) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 2) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 3) chain A residue 156 type sequence K description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 4) chain A residue 311 type sequence A description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 5) chain A residue 315 type sequence T description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 6) chain A residue 376 type sequence P description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 7) chain A residue 377 type sequence I description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 8) chain A residue 380 type sequence M description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 9) chain A residue 382 type sequence R description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 10) chain A residue 441 type sequence P description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 11) chain A residue 442 type sequence F description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 12) chain A residue 443 type sequence G description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 13) chain A residue 447 type sequence H description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 14) chain A residue 449 type sequence C description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 15) chain A residue 450 type sequence I description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 16) chain A residue 451 type sequence G description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 17) chain A residue 455 type sequence A description BINDING SITE FOR RESIDUE HEM A 540 source : AC1 18) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 19) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 20) chain A residue 135 type sequence T description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 21) chain A residue 139 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 22) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 23) chain A residue 159 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 24) chain A residue 234 type sequence F description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 25) chain A residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 26) chain A residue 304 type sequence M description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 27) chain A residue 307 type sequence G description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 28) chain A residue 308 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 29) chain A residue 310 type sequence L description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 30) chain A residue 311 type sequence A description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 31) chain A residue 377 type sequence I description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 32) chain A residue 487 type sequence M description BINDING SITE FOR RESIDUE VFV A 580 source : AC2 33) chain A residue 77 type sequence F description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 34) chain A residue 100 type sequence M description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 35) chain A residue 101 type sequence V description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 36) chain A residue 105 type sequence F description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 37) chain A residue 107 type sequence Y description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 38) chain A residue 236 type sequence H description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 39) chain A residue 239 type sequence W description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 40) chain A residue 379 type sequence I description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 41) chain A residue 381 type sequence M description BINDING SITE FOR RESIDUE VFV A 600 source : AC3 42) chain A residue 245 type sequence L description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 43) chain A residue 246 type sequence P description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 44) chain A residue 247 type sequence L description BINDING SITE FOR RESIDUE VFV B 600 source : AC6 45) chain A residue 442-451 type prosite sequence FGAGRHRCIG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGRHRCIG source prosite : PS00086 46) chain A residue 204-209 type prosite sequence LTASHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTASHC source prosite : PS00134 47) chain A residue 455 type BINDING sequence A description axial binding residue => ECO:0000269|PubMed:20149798 source Swiss-Prot : SWS_FT_FI1

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