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eF-site ID
|
4ue7-H |
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PDB Code
|
4ue7 |
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Chain
|
H |
|
click to enlarge
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Title
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Thrombin in complex with 1-amidinopiperidine |
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Classification
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HYDROLASE |
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Compound
|
THROMBIN HEAVY CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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H: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPI
VERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLK
KWIQKVIDQFG
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Description
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Functional site
|
|
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1)
|
chain |
H |
| residue |
53-58 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
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2)
|
chain |
H |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
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| source |
prosite : PS00135
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3)
|
chain |
H |
| residue |
102 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:3513162
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
H |
| residue |
195 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:3513162
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
H |
| residue |
60 |
| type |
CARBOHYD |
| sequence |
L
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
|
| source |
Swiss-Prot : SWS_FT_FI2
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