eF-site ID 4ubv-B PDB Code 4ubv Chain B click to enlarge Title Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA Classification TRANSFERASE Compound Acetyl-CoA acetyltransferase FadA5 Source Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (I6XHI4_MYCTU) Sequence B:  SMGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVD KAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAG LPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACG IEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIA KRRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAP VLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGI HTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQAL VGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFA SVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITT ALHELERTDQSLALITMCAGGALSTGTIIERI Description Functional site 1) chain B residue 162 type sequence R description binding site for residue SO4 A 403 source : AC1 2) chain B residue 292 type sequence V description binding site for residue DIO A 406 source : AC4 3) chain B residue 16 type sequence K description binding site for residue COA B 401 source : AC9 4) chain B residue 17 type sequence R description binding site for residue COA B 401 source : AC9 5) chain B residue 93 type sequence C description binding site for residue COA B 401 source : AC9 6) chain B residue 128 type sequence L description binding site for residue COA B 401 source : AC9 7) chain B residue 151 type sequence Q description binding site for residue COA B 401 source : AC9 8) chain B residue 152 type sequence F description binding site for residue COA B 401 source : AC9 9) chain B residue 221 type sequence R description binding site for residue COA B 401 source : AC9 10) chain B residue 222 type sequence E description binding site for residue COA B 401 source : AC9 11) chain B residue 223 type sequence T description binding site for residue COA B 401 source : AC9 12) chain B residue 231 type sequence L description binding site for residue COA B 401 source : AC9 13) chain B residue 242 type sequence A description binding site for residue COA B 401 source : AC9 14) chain B residue 243 type sequence G description binding site for residue COA B 401 source : AC9 15) chain B residue 245 type sequence S description binding site for residue COA B 401 source : AC9 16) chain B residue 246 type sequence S description binding site for residue COA B 401 source : AC9 17) chain B residue 248 type sequence I description binding site for residue COA B 401 source : AC9 18) chain B residue 317 type sequence A description binding site for residue COA B 401 source : AC9 19) chain B residue 318 type sequence F description binding site for residue COA B 401 source : AC9 20) chain B residue 347 type sequence H description binding site for residue COA B 401 source : AC9 21) chain B residue 349 type sequence V description binding site for residue COA B 401 source : AC9 22) chain B residue 275 type sequence V description binding site for residue SO4 B 402 source : AD1 23) chain B residue 302 type sequence A description binding site for residue SO4 B 402 source : AD1 24) chain B residue 48 type sequence H description binding site for residue DIO B 403 source : AD2 25) chain B residue 49 type sequence A description binding site for residue DIO B 403 source : AD2 26) chain B residue 50 type sequence G description binding site for residue DIO B 403 source : AD2 27) chain B residue 81 type sequence P description binding site for residue DIO B 403 source : AD2 28) chain B residue 213 type sequence L description binding site for residue DIO B 404 source : AD3 29) chain B residue 214 type sequence V description binding site for residue DIO B 404 source : AD3 30) chain B residue 215 type sequence F description binding site for residue DIO B 404 source : AD3 31) chain B residue 216 type sequence R description binding site for residue DIO B 404 source : AD3 32) chain B residue 225 type sequence M description binding site for residue DIO B 405 source : AD4 33) chain B residue 20 type sequence W description binding site for residue DIO B 407 source : AD6 34) chain B residue 212 type sequence R description binding site for residue DIO B 407 source : AD6 35) chain B residue 48 type sequence H description binding site for residue GOL B 408 source : AD7 36) chain B residue 81 type sequence P description binding site for residue GOL B 408 source : AD7 37) chain B residue 82 type sequence E description binding site for residue GOL B 408 source : AD7 38) chain B residue 83 type sequence H description binding site for residue GOL B 408 source : AD7 39) chain B residue 128 type sequence L description binding site for residue GOL B 409 source : AD8 40) chain B residue 136 type sequence R description binding site for residue GOL B 409 source : AD8 41) chain B residue 326 type sequence A description binding site for residue GOL B 410 source : AD9 42) chain B residue 330 type sequence E description binding site for residue GOL B 410 source : AD9 43) chain B residue 331 type sequence P description binding site for residue GOL B 410 source : AD9 44) chain B residue 333 type sequence M description binding site for residue GOL B 410 source : AD9 45) chain B residue 323 type sequence L description binding site for residue GOL B 411 source : AE1 46) chain B residue 333 type sequence M description binding site for residue GOL B 411 source : AE1 47) chain B residue 178 type sequence R description binding site for residue GOL B 412 source : AE2 48) chain B residue 182 type sequence R description binding site for residue GOL B 412 source : AE2 49) chain B residue 175 type sequence E description binding site for residue GOL B 413 source : AE3 50) chain B residue 178 type sequence R description binding site for residue GOL B 413 source : AE3 51) chain B residue 179 type sequence R description binding site for residue GOL B 413 source : AE3 52) chain B residue 182 type sequence R description binding site for residue GOL B 413 source : AE3 53) chain B residue 334 type sequence D description binding site for residue GOL B 413 source : AE3 54) chain B residue 220 type sequence L description binding site for residue GOL B 415 source : AE5 55) chain B residue 246 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBU, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI6 56) chain B residue 93 type ACT_SITE sequence C description Acyl-thioester intermediate => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI1 57) chain B residue 347 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI2 58) chain B residue 377 type ACT_SITE sequence C description Proton acceptor => ECO:0000305|PubMed:25482540 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 151 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 60) chain B residue 379 type BINDING sequence G description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 61) chain B residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI5

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