eF-site ID 4ubv-AB PDB Code 4ubv Chain A, B click to enlarge Title Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA Classification TRANSFERASE Compound Acetyl-CoA acetyltransferase FadA5 Source Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (I6XHI4_MYCTU) Sequence A:  MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDK AGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGL PEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGI EAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAK RRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPV LDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALV GAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFAS VVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTA LHELERTDQSLALITMCAGGALSTGTIIERI B:  SMGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVD KAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAG LPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACG IEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIA KRRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAP VLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGI HTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQAL VGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFA SVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITT ALHELERTDQSLALITMCAGGALSTGTIIERI Description Functional site 1) chain B residue 162 type sequence R description binding site for residue SO4 A 403 source : AC1 2) chain A residue 28 type sequence E description binding site for residue SO4 A 404 source : AC2 3) chain A residue 196 type sequence I description binding site for residue SO4 A 404 source : AC2 4) chain A residue 197 type sequence Q description binding site for residue SO4 A 404 source : AC2 5) chain A residue 17 type sequence R description binding site for residue DIO A 405 source : AC3 6) chain A residue 18 type sequence N description binding site for residue DIO A 405 source : AC3 7) chain A residue 264 type sequence R description binding site for residue DIO A 406 source : AC4 8) chain B residue 292 type sequence V description binding site for residue DIO A 406 source : AC4 9) chain A residue 20 type sequence W description binding site for residue GOL A 407 source : AC5 10) chain A residue 212 type sequence R description binding site for residue GOL A 407 source : AC5 11) chain A residue 46 type sequence G description binding site for residue GOL A 408 source : AC6 12) chain A residue 81 type sequence P description binding site for residue GOL A 408 source : AC6 13) chain A residue 82 type sequence E description binding site for residue GOL A 408 source : AC6 14) chain A residue 83 type sequence H description binding site for residue GOL A 408 source : AC6 15) chain A residue 161 type sequence R description binding site for residue GOL A 409 source : AC7 16) chain A residue 162 type sequence R description binding site for residue GOL A 409 source : AC7 17) chain A residue 163 type sequence G description binding site for residue GOL A 409 source : AC7 18) chain A residue 333 type sequence M description binding site for residue GOL A 410 source : AC8 19) chain B residue 16 type sequence K description binding site for residue COA B 401 source : AC9 20) chain B residue 17 type sequence R description binding site for residue COA B 401 source : AC9 21) chain B residue 93 type sequence C description binding site for residue COA B 401 source : AC9 22) chain B residue 128 type sequence L description binding site for residue COA B 401 source : AC9 23) chain B residue 151 type sequence Q description binding site for residue COA B 401 source : AC9 24) chain B residue 152 type sequence F description binding site for residue COA B 401 source : AC9 25) chain B residue 221 type sequence R description binding site for residue COA B 401 source : AC9 26) chain B residue 222 type sequence E description binding site for residue COA B 401 source : AC9 27) chain B residue 223 type sequence T description binding site for residue COA B 401 source : AC9 28) chain B residue 231 type sequence L description binding site for residue COA B 401 source : AC9 29) chain B residue 242 type sequence A description binding site for residue COA B 401 source : AC9 30) chain B residue 243 type sequence G description binding site for residue COA B 401 source : AC9 31) chain B residue 245 type sequence S description binding site for residue COA B 401 source : AC9 32) chain B residue 246 type sequence S description binding site for residue COA B 401 source : AC9 33) chain B residue 248 type sequence I description binding site for residue COA B 401 source : AC9 34) chain B residue 317 type sequence A description binding site for residue COA B 401 source : AC9 35) chain B residue 318 type sequence F description binding site for residue COA B 401 source : AC9 36) chain B residue 347 type sequence H description binding site for residue COA B 401 source : AC9 37) chain B residue 349 type sequence V description binding site for residue COA B 401 source : AC9 38) chain B residue 275 type sequence V description binding site for residue SO4 B 402 source : AD1 39) chain B residue 302 type sequence A description binding site for residue SO4 B 402 source : AD1 40) chain B residue 48 type sequence H description binding site for residue DIO B 403 source : AD2 41) chain B residue 49 type sequence A description binding site for residue DIO B 403 source : AD2 42) chain B residue 50 type sequence G description binding site for residue DIO B 403 source : AD2 43) chain B residue 81 type sequence P description binding site for residue DIO B 403 source : AD2 44) chain A residue 190 type sequence D description binding site for residue DIO B 404 source : AD3 45) chain B residue 213 type sequence L description binding site for residue DIO B 404 source : AD3 46) chain B residue 214 type sequence V description binding site for residue DIO B 404 source : AD3 47) chain B residue 215 type sequence F description binding site for residue DIO B 404 source : AD3 48) chain B residue 216 type sequence R description binding site for residue DIO B 404 source : AD3 49) chain B residue 225 type sequence M description binding site for residue DIO B 405 source : AD4 50) chain A residue 20 type sequence W description binding site for residue DIO B 406 source : AD5 51) chain A residue 215 type sequence F description binding site for residue DIO B 406 source : AD5 52) chain A residue 216 type sequence R description binding site for residue DIO B 406 source : AD5 53) chain B residue 20 type sequence W description binding site for residue DIO B 407 source : AD6 54) chain B residue 212 type sequence R description binding site for residue DIO B 407 source : AD6 55) chain B residue 48 type sequence H description binding site for residue GOL B 408 source : AD7 56) chain B residue 81 type sequence P description binding site for residue GOL B 408 source : AD7 57) chain B residue 82 type sequence E description binding site for residue GOL B 408 source : AD7 58) chain B residue 83 type sequence H description binding site for residue GOL B 408 source : AD7 59) chain B residue 128 type sequence L description binding site for residue GOL B 409 source : AD8 60) chain B residue 136 type sequence R description binding site for residue GOL B 409 source : AD8 61) chain B residue 326 type sequence A description binding site for residue GOL B 410 source : AD9 62) chain B residue 330 type sequence E description binding site for residue GOL B 410 source : AD9 63) chain B residue 331 type sequence P description binding site for residue GOL B 410 source : AD9 64) chain B residue 333 type sequence M description binding site for residue GOL B 410 source : AD9 65) chain B residue 323 type sequence L description binding site for residue GOL B 411 source : AE1 66) chain B residue 333 type sequence M description binding site for residue GOL B 411 source : AE1 67) chain B residue 178 type sequence R description binding site for residue GOL B 412 source : AE2 68) chain B residue 182 type sequence R description binding site for residue GOL B 412 source : AE2 69) chain B residue 175 type sequence E description binding site for residue GOL B 413 source : AE3 70) chain B residue 178 type sequence R description binding site for residue GOL B 413 source : AE3 71) chain B residue 179 type sequence R description binding site for residue GOL B 413 source : AE3 72) chain B residue 182 type sequence R description binding site for residue GOL B 413 source : AE3 73) chain B residue 334 type sequence D description binding site for residue GOL B 413 source : AE3 74) chain A residue 186 type sequence E description binding site for residue GOL B 415 source : AE5 75) chain B residue 220 type sequence L description binding site for residue GOL B 415 source : AE5 76) chain A residue 337-353 type prosite sequence NVNGGAIALGHPVGCTG description THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPvGcTG source prosite : PS00737 77) chain A residue 93 type ACT_SITE sequence C description Acyl-thioester intermediate => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI1 78) chain B residue 93 type ACT_SITE sequence C description Acyl-thioester intermediate => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI1 79) chain A residue 347 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI2 80) chain B residue 347 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:25482540, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI2 81) chain A residue 377 type ACT_SITE sequence C description Proton acceptor => ECO:0000305|PubMed:25482540 source Swiss-Prot : SWS_FT_FI3 82) chain B residue 377 type ACT_SITE sequence C description Proton acceptor => ECO:0000305|PubMed:25482540 source Swiss-Prot : SWS_FT_FI3 83) chain A residue 151 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 84) chain A residue 379 type BINDING sequence G description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 85) chain B residue 151 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 86) chain B residue 379 type BINDING sequence G description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT source Swiss-Prot : SWS_FT_FI4 87) chain A residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI5 88) chain B residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI5 89) chain A residue 246 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBU, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI6 90) chain B residue 246 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25482540, ECO:0007744|PDB:4UBT, ECO:0007744|PDB:4UBU, ECO:0007744|PDB:4UBV source Swiss-Prot : SWS_FT_FI6

Display surface Download Links