eF-site ID 4u8z-A PDB Code 4u8z Chain A click to enlarge Title Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06447475) Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase 24 Source Homo sapiens (Human) (STK24_HUMAN) Sequence A:  GLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGS YLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREI LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ LTDTQIKRNXFVGTPFWMAPEVIKQSAYDSKADIWSLGIT AIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLK EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI DRYKRWKAEQ Description Functional site 1) chain A residue 162 type sequence D description binding site for residue MN A 301 source : AC1 2) chain A residue 30 type sequence I description binding site for residue 3FE A 302 source : AC2 3) chain A residue 31 type sequence G description binding site for residue 3FE A 302 source : AC2 4) chain A residue 32 type sequence K description binding site for residue 3FE A 302 source : AC2 5) chain A residue 51 type sequence A description binding site for residue 3FE A 302 source : AC2 6) chain A residue 53 type sequence K description binding site for residue 3FE A 302 source : AC2 7) chain A residue 70 type sequence E description binding site for residue 3FE A 302 source : AC2 8) chain A residue 100 type sequence E description binding site for residue 3FE A 302 source : AC2 9) chain A residue 101 type sequence Y description binding site for residue 3FE A 302 source : AC2 10) chain A residue 102 type sequence L description binding site for residue 3FE A 302 source : AC2 11) chain A residue 151 type sequence L description binding site for residue 3FE A 302 source : AC2 12) chain A residue 161 type sequence A description binding site for residue 3FE A 302 source : AC2 13) chain A residue 162 type sequence D description binding site for residue 3FE A 302 source : AC2 14) chain A residue 178 type MOD_RES sequence X description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:20124694, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 30-53 type prosite sequence IGKGSFGEVFKGIDNRTQKVVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGEVFkGidnrtqkv..........VAIK source prosite : PS00107 16) chain A residue 144 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 30 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 18) chain A residue 53 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 19) chain A residue 100 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 149 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 162 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 18 type MOD_RES sequence A description Phosphothreonine; by PKA => ECO:0000269|PubMed:10644707 source Swiss-Prot : SWS_FT_FI3

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